克拉霉素微囊的制备及其质量评价  

Preparation and Quality Evaluation of Clarithromycin Microcapsules

作　　者：胡连栋[1] 赵吉强[1] 杨更亮[1] 

机构地区：[1]河北大学药学院,保定市071002

出　　处：《中国药房》2009年第13期1000-1002,共3页China Pharmacy

基　　金：河北大学引进人才资助项目(y2005064)

摘　　要：目的:制备克拉霉素微囊并对其质量进行评价。方法:以乙基纤维素为囊材,采用乳化-溶剂挥发法制备克拉霉素微囊,并对微囊粒径、包封率和载药量、体外释药性进行考察。结果:所制微囊粒径分布均匀,粒径33.0～38.0μm,包封率在87%以上,载药量大于45%,6h时累积释药量达75%。结论:该制剂制备方法简便易行,质量评价合格。OBJECTIVE： To prepare and evaluate the quality of clarithromycin microcapsules. METHODS： Clarithromycin microeapsules were prepared by emulsionsolvent volatilixation method using ethylcellulose as capsule wall material. The particle size, entrapment efficiency, the loading amount and the drug release property in vitro were investigated. RESULTS： The prepared microcapsules were well- distributed in particle size with average particle size at 33.0～38.0μm, encapsulation efficiency at above 87%, loading amount above 45%, and accumulative drug release rate of 75% at 6h. CONCLUSION： The method is simple and feasible and the quality of prepared mierocapsules is up to the standard.

关 键 词：克拉霉素 微囊 制备 质量评价 

分 类 号：TQ460.6[化学工程—制药化工] R978.15[医药卫生—药品]