维生素D受体Apal位点基因多态性与新疆南部维吾尔族泌尿系结石患者的相关性研究  

Study on the Relationship Between Vitamin D Receptor Gene Apa1 Polymorphism and Urinary Stone Disease of Chinese uygur in XinJiang South

作　　者：郭爱菊[1] 钱彪[1] 丁国富[1] 王勤章[1] 

机构地区：[1]石河子大学医学院第一附属医院泌尿外科,新疆石河子832008

出　　处：《农垦医学》2009年第1期4-6,共3页Journal of Nongken Medicine

基　　金：新疆生产建设兵团博士基金项目;项目编号:2007JC14

摘　　要：目的:探讨维生素D受体(VDR)Apal位点多态性与新疆南部维吾尔族泌尿系结石之间的关系。方法:收集90例维吾尔族泌尿系结石患者和90例维吾尔族正常对照者。采用聚合酶链反应(PCR)和限制性酶切法研究VDR的Apal位点多态性与草酸钙尿结石之间的关系。结果:Apal酶切位点病例组和正常对照组AA、Aa、aa 3种基因型频率的差异有统计学意义(x^2=14.22,p<0.001),基因型Aa在病例组占63.3%,明显高于对照组(35. 6%),差异亦有统计学意义。结论:维生素D受体基因多态性与泌尿系结石有关,Aa基因型可能是泌尿系结石的易感基因,VDR-Apal位点有望成为筛选和检测泌尿系结石的一个指标。Objective： To elucidate the relatonship between vitamin D receptor gene polymerphism and urinary stone disease of Chinese uygur in XinJiang South. Methods： 90 Urinary Stone Disease patients and 90 normal controls were ineluded. Polymerase chain reaction （PCR） and restriction endonuclease analysis were used to detect Apal of ditamin D receptor gene type. Resets： The genotype frequency distribution of Apal allele polymorphism in the urinary stone disease patients was significantly different from that in the control group too （χ^2 = 14.22, P〈0.001 ）. The frequency of the Aa genetype in the patients（63.3% ） was higher than in the control group（35.6% ）. Conclusion： The polymorphism of vita -rain D receptor gene has effect on urinary stone disease. Aa genotype is probably a genetic susceptible marker of urinary stone disease.

关 键 词：泌尿系结石 维生素D受体 基因多态性 维吾尔族 

分 类 号：Q754[生物学—分子生物学] R691.4[医药卫生—泌尿科学]