伴抑郁障碍的冠心病患者的临床对照研究  

Clinical Contral Study on Patients with Cardiovascular Diseases Accompanied by Depression

作　　者：马建华[1] 李雅忠[1] 徐建国[1] 翟鹭[2] 

机构地区：[1]河北省唐山市第五医院,中国063000 [2]中国人民大学劳动人事学院人力资源系

出　　处：《中国健康心理学杂志》2009年第4期475-477,共3页China Journal of Health Psychology

摘　　要：目的探讨舍曲林对抑郁障碍的冠心病患者的治疗效果及其临床意义。方法对48例伴抑郁障碍冠心病患者,进行8周的随机对照研究。实验组、对照组各24例。以BECK抑郁问卷（BDI）和汉密尔顿抑郁量表（HAMD）评定疗效,心电图监测冠心病缓解情况。结果实验组抑郁症状的减轻明显优于对照组（P〈0.05~0.01）,根据BDI评分实验组的显效率明显高于对照组（62.5%,33.3%,P〈0.05）,根据HAM D评分,实验组的治愈率高于对照组（45.8%,25.0%,P〈0.05）,实验组冠心病相关症状的显效率比对照组更明显。结论舍曲林能有效的减轻冠心病患者的抑郁症状,这种治疗更有利于冠心病的控制。Objective To explore the effect of Sertraline hydrochloride for depression in patients with cardiovascular diseases. Methods 48 patients with cardiovascular diseases and major depreesive disorder entered an 8-week randomized control trial. Patients of experimental group were given daily doses of Sertraline hydrochloride （up to 100mg/d）. The beck Depression Inventory （BDI） and Hamilton Rating Scale for Depression （HAMD） were used to measure the severity of depression and to detemine the percentage of patients who achived substantial improvement or complete remission. Results The depreesive symptoms of experimental group were much lighter than those of the control （P〈0. 05 or P〈0. 01）. The effectiveness rate of experimental group were much higher than that of the control （62.5%, 33.3%, P〈0. 05） according to BDI and the cure rate of experimental group were higher than that of the control （45.8%, 25.0%, P〈0. 05） according to HAMD. The symptoms related to cardiovascular diseases of experimental group markedly improved compared with the control. Conclusion Doctors should pay attention to the prevalence of depression in patients with cardiovascular diseases. There is an apparently therapeutic effect after administering Sertraline hydrochloride.

关 键 词：冠心病 病例对照研究 抑郁 舍曲林 

分 类 号：R541.4[医药卫生—心血管疾病] R749.4[医药卫生—内科学]