不同年龄患者左旋布比卡因硬膜外麻醉药效学和安全性  

The Effect of Age on Pharmacodynamics and Safety of Levobupivacaine for Epidural Anesthesia

作　　者：王元[1] 王艳萍[1] 马民玉[1] 

机构地区：[1]郑州大学第一附属医院麻醉科,河南郑州450052

出　　处：《医学与哲学（B）》2009年第4期35-36,48,共3页Medicine & Philosophy(B)

基　　金：河南省科技攻关项目;项目编号:0624420030

摘　　要：探讨不同年龄患者左旋布比卡因硬膜外麻醉的药效学和安全性。60例行下肢手术患者,按年龄分为三组,每组20例。左旋布比卡因用量1.8mg.kg-1。观察并记录注药后感觉及运动阻滞情况、评价麻醉效果、监测麻醉期间血流动力学和心电图变化及不良反应发生情况。结果是最大感觉阻滞平面Ⅰ组高于Ⅲ组,感觉及运动阻滞维持时间Ⅰ组均长于Ⅲ组(P<0.05);三组麻醉优良率均达100%;麻醉期间血流动力学变化均较稳定;不良反应发生率均较低。结论为不同年龄患者0.75%左旋布比卡因硬膜外麻醉安全有效,年龄对其药效学有明显影响。To investigate the effects of age on the pharmacodynamics and safety of levobupivacaine used for epidural anesthesia, 60 patients scheduled to undergo elective lower extremity surgery under epidural anesthesia were enrolled in one of three age groups. All patients received 0. 75% levobupivacaine 1.8mg· kg-1. Assessments of sensory and motor block were made. The effect of anesthesia was also assessed. The changes of hemodynamic and ECG were monitored continuously at set intervals. The adverse reactions were recorded. The results show that the maximal cehpalad spread level in Group Ⅰ was higher than that in Group Ⅲ （P〈0.05） and the time until total recovery from sensory and motor block were longer than those in Group Ⅲ （P〈0.05）. The indexes of hemodynamic were all stable . The incidences of adverse reactions were low. The conclusions show that 0. 75% levobupivacaine for epidural anesthesia is safe and effective on different age pa- tients. There was significant influrance of age on the pharmaeodynamic of levobupivaeaine after epidural administration.

关 键 词：左旋布比卡因 硬膜外麻醉 年龄 药效学 

分 类 号：R971.2[医药卫生—药品]