羟苯磺酸钙与培哚普利对早期糖尿病肾病大鼠的治疗作用比较  

Therapeutical Effect Comparison of Calcium Dobesilate and Perindopril on Kidney of Rats with Early Diabetic Nephropathy

作　　者：高美娟[1] 李波[1] 刘明[2] 李明龙[3] 卞丽香[1] 于桂娜[1] 

机构地区：[1]山东大学附属省立医院内分泌科,山东济南250021 [2]山东大学附属省立医院核医学科,山东济南250021 [3]山东大学附属省立医院保健科,山东济南250021

出　　处：《医学与哲学（B）》2009年第4期49-51,54,共4页Medicine & Philosophy(B)

基　　金：山东省科技厅有资项目;项目编号:2001BB1DBA1

摘　　要：观察羟苯磺酸钙和培哚普利对早期糖尿病肾病大鼠肾脏的治疗作用的差别。测定24h尿白蛋白,血浆及肾皮质ET(内皮素,endothelin)含量,肾皮质PAI-1(纤溶酶原激活物抑制剂-1,plasminogen activator inhibitor-1)、MMP-9(基质金属蛋白酶-9,matrix metalloproteinase-9)表达,观察肾脏病理形态变化。从结果看,羟苯磺酸钙可以减轻实验大鼠肾脏损伤,作用与培哚普利无明显差别。The aim of this study is to observe the effect of calcium dobesilate and perindopril on streptozotocin --induced early diabetic nephrophthy in rats. 24--h urinary albumin, endothelin in plasma and kidney cortex, plasminogen activator inhibitor-1 and matrix metalloprotein-9 in cortex of kidney were measured. Renal pathomorphism was observed. All findings suggested that calcium dobesilate could ameliorate renal injury and there were no differences between calcium dobesilate and perindopril on the therapeutical effects.

关 键 词：羟苯磺酸钙 糖尿病肾病 血管紧张素转换酶抑制剂 纤溶酶原激活物抑制剂-1 基质金属蛋白酶-9 内皮素 

分 类 号：R587.1[医药卫生—内分泌]