不可分型流行性感冒嗜血杆菌致病机制研究进展  

Progress Toward Molecular Determinants of the Pathogenesis of Disease Due to Nontypeable Haemophilus influenzae

作　　者：田国忠[1] 张砺[2] 邵祝军[1] 

机构地区：[1]中国疾病预防控制中心传染病预防控制所,北京102206 [2]成都市儿童医院,四川成都610017

出　　处：《中国疫苗和免疫》2009年第2期174-179,共6页Chinese Journal of Vaccines and Immunization

摘　　要：流行性感冒(流感)嗜血杆菌(Haemophilus Influenzae,Hi)分为有荚膜的可分型(a～f型)和无荚膜的不可分型菌株,有荚膜的b型Hi(Hi Type b,Hib)是引起侵袭性感染,包括脑膜炎、肺炎的主要病原体,但Hib的感染有疫苗可以预防。不可分型Hi是导致儿童感染的重要病原体之一,可引起多种疾病,包括肺炎、中耳炎等,目前无疫苗预防。现将国内外对不可分型Hi的致病因子和致病机理进行综述,为疫苗的研制、疾病的治疗和预防控制提供帮助。Haemophilus influenzae （Hi） is a pathogen exclusively found in humans. It causes a wide range of infections from the upper respiratory tract to serious invasive diseases. Such as pneumonia, septicemia and meningitis. Strains of Hi are usually classified into six serotypes a to f and nontypeable H. infiuenzae （NTHI） according to the antigenicities and compositions of their polysaccharide capsules. Hib was a common cause of serious infections in younger children. The polysaccharide-protein conjugate vaccines against Hib had almost eliminated H. influenzae as a cause of pediatric meningitis. However, NTHI remains an important pathogen, particularly in children and the elderly. Efforts to understand and control NTHI disease have been hampered by the diversity of these bacteria. This review introduced the study progress about pathogenic mechanism of NTHI. In order to provide the help for development of vaccine, clinic treatment and prevent the occurrence of diseases causing by NTHI.

关 键 词：不可分型流行性感冒嗜血杆菌 分子因素 致病机制 

分 类 号：R378.4[医药卫生—病原生物学]