内蒙古地区HDCP疾病与人类白细胞抗原多态性研究  

Study on The Polymorphisms of HLA and Hypertensive Disorder Complicating Pregnancy in Inner Mongolia Population

作　　者：杨军[1] 刘惠琴[1] 

机构地区：[1]包头市中心医院妇产科,内蒙古包头014040

出　　处：《内蒙古医学杂志》2009年第3期264-266,共3页Inner Mongolia Medical Journal

摘　　要：目的:检测内蒙古地区HDCP患者HLA基因HLA-A,HLA-B位点与HDCP的相关性。方法:采用国内先进的FLOW-SSOP(Luminex流式技术-序列特异性寡核苷酸探针反向杂交)技术检测A、B位点基因频率及基因型频率分布,分析妊娠期高血压疾病与HLA-I类抗原的关系。结果:妊娠期高血压组HLA-A、B位点等位基因的基因频率与正常妊娠组无显著差异(P>0.05)。结论:内蒙古地区妊娠期高血压疾病的发生与HLA-I类抗原无关。Objective：To study the relativity between the poiyrnorphisms of HLA- A, B and hypertensive disorder complicating pregnancy（HDCP）in Inner Mongolia population. Methods： The genotyping of HLA- A, B was done by Flow Gytometry- Sequence Specific Oligonucleotide Probes （FLOW- SSOP） in 40 HDCP and 80 healthy controls from Inner Mongolia. Analyzed the relationship of HDCP with HLA- Ⅰ. Results：There was no significant difference in the frequency of HLA- A, B between the HDCP group and the control group （P 〉 0.05）. Conclusion： There was no correlation between the HDCP and HLA in Inner Mongolia population.

关 键 词：妊娠期高血压疾病 人类白细胞抗原 多态性 

分 类 号：R714.24[医药卫生—妇产科学]