SOD模拟及其抗氧化和抗炎症功能的研究进展  

Achievement in SOD Mimics with Antioxidant and Anti-Inflammation Functions

作　　者：胡平[1] 吴耿伟[1] 夏青[2] 毛宗万[1] 

机构地区：[1]中山大学化学与化学工程学院生物无机与合成化学教育部重点实验室/有害生物控制与资源利用国家重点实验室,广州510275 [2]北京大学药学院,北京100191

出　　处：《化学进展》2009年第5期873-879,共7页Progress in Chemistry

基　　金：国家自然科学基金项目(No.30770494,20831006);广东省自然科学基金项目(No.07117637);国家重点基础研究发展计划(973)项目(No.2007CB815306)资助

摘　　要：超氧化物歧化酶(superoxide dismutase,简称SOD)作为生物体内超氧离子自由基的清除剂,具备有效抗氧化、抗炎症、抗衰老之功效,并用于临床,其化学模拟引起了人们的广泛研究兴趣。本文将简要介绍近年来SOD人工模拟酶及其生物医学活性研究所取得的重要进展,特别是Cu,Zn-SOD模拟物结构与功能的相互关系、Mn-SOD模拟物的生物活性及其医学应用。As effective radical scavengers in vivo, superoxide dismutases （SODs） have the antioxidant, antiinflammation and anti-aging functions, and have been applied in clinical treatments as drugs. Therefore, there is still an increasing interest in design and development of artificial SODs for potential application. In this article, a brief introduction about the research achievement of SOD mimics and their biomedical activities during past decade is shown.Our attention focuses on the relation between the structure and biological function of Cu, Zn-SOD mimics as well as the bio-activity and application of Mn-SOD mimics in medicine.

关 键 词：超氧化物歧化酶 SOD模拟物 抗氧化 抗炎症 

分 类 号：Q55[生物学—生物化学]