从钒化合物生物效应的多样性看其作用机制  

Mechanisms Underlying Diversified Biological Effects of Vanadium Compounds

作　　者：杨晓改[1] 王琴[1] 刘竟成[1] 王夔[1] 

机构地区：[1]北京大学药学院化学生物学系,北京100191

出　　处：《化学进展》2009年第5期890-895,共6页Progress in Chemistry

基　　金：国家自然科学基金项目(No.20871008);北京大学药学院青年教师启动基金项目资助

摘　　要：本文对近年来关于钒化合物不同生物效应机制的研究进展进行了总结,着重于其类胰岛素和抗癌效应的信号转导机制以及两者之间的相关性。同时,基于钒化合物对磷酸转移反应的干预以及对细胞氧化还原状态的调节,讨论了钒化合物多样化的生物效应是否具有一个共同作用机制的可能性,并提出了未来钒化合物研究方向和所面临的挑战。In this review, the authors present a brief overview of recent research progress on the diversified biological effects of vanadium compounds. This review focuses on the signaling mechanisms underlying pathways mediating the insulin-mimetic and anticancer effects of vanadium compounds, as well as the correlationship between them. Besides, based on their intervention on phosphate transfer reactions and roles in modulating cellular redox reactions, the possibility of a universal mechanism is discussed. Finally, both the tendency and the challenge in the vanadium research are indicated.

关 键 词：类胰岛素 抗癌 钒化合物 

分 类 号：O614.5[理学—无机化学] Q591.2[理学—化学]