钒化合物抗糖尿病作用的研究进展  

Research Progress in Anti-Diabetic Effects of Vanadium Compounds

作　　者：韦丹[1] 丁文军[1] 周桔[1] 彭端[1] 李明[1] 

机构地区：[1]中国科学院研究生院生命科学学院环境与健康研究室,北京100049

出　　处：《化学进展》2009年第5期896-902,共7页Progress in Chemistry

基　　金：国家自然科学基金项目(No.20571084;20871120)资助

摘　　要：在糖尿病的治疗研究中,体内和体外的研究表明,钒化合物可以降低Ⅰ型和Ⅱ型糖尿病血糖,促进葡萄糖转运和糖原合成,具有"类胰岛素作用"。本文综述了近年来钒化合物在降低和改善糖尿病症状的生物效应及其通过胰岛素信号通路在降糖作用的分子机制的研究进展。It is well known that diabetes mellitus （DM） is a chronic disease caused by inherited and/or acquired deficiency in production of insulin by the pancreas, or by the ineffectiveness of the insulin produced. Numerous studies have shown that vanadium and its compounds improve glucose homeostasis and insulin resistance in Type Ⅰ and Type Ⅱdiabetes mellitus. Vanadium and its compounds appear to have a profound impact on insulin action through the insulin signaling cascade, but the underlying mechanism is not fully understood. This review summarizes recent work to identify the effects of pharmaceutical treatment of vanadium compounds on insulin signaling and glucose uptake, in an attempt to characterize the molecular mechanism accounting for biological actions and insulin-mimesis of vanadium compounds in DM.

关 键 词：钒化合物 糖尿病 抗糖尿病作用 

分 类 号：O614.511[理学—无机化学] R151.2[理学—化学]