eIF-5A与DHS功能研究及应用进展  

The Progress of the Study on eIF-5A and DHS and Associated Applications

作　　者：时广红[1,2] 王彦珍[2] 魏建华[2] 

机构地区：[1]首都师范大学,北京100048 [2]北京农业生物技术研究中心,北京100097

出　　处：《生物技术通报》2009年第5期21-26,共6页Biotechnology Bulletin

基　　金：北京市科技新星计划项目(2005B22)

摘　　要：脱氧羟腐胺赖氨酸合酶(deoxyhypusine synthase,DHS)在植物、哺乳动物和酵母细胞中普遍存在,参与真核翻译起始因子eIF-5A(eukaryotic initiation factor-5A)的翻译后活化。目前研究表明eIF-5A具有多重生物学功能,如参与细胞增殖、蛋白质翻译、mRNA降解、细胞周期的转化及细胞衰老与凋亡等。eIF-5A是目前已知的DHS的惟一底物,因此研究DHS的功能与作用机理离不开对eIF-5A的功能研究。DHS （Deoxyhypusine Synthase, DHS） which exits widely in plants, mammals and yeast cells, play a role in the posttranslational activation of eIF-SA（ eukaryotic initiation factor-SA）, eIF-SA known as substrate has been involved in many cellular activities, such as cell proliferation,protein translation,mRNA degradation, cell cycle and cell senescence and apoptosis. In addition,this ar- ticle aimed to review the recent study on the DHS based on associated laboratory work.

关 键 词：DHS EIF-5A 植物遗传改良 

分 类 号：Q75[生物学—分子生物学]