X射线衍射技术在抗癌新药顺二氯二氨合铂的合成与结构研究中的应用  

Synthesizing and structures of platinum anticancer complexs by method of X ray diffraction

作　　者：王德华[1,2,3] 张静[1,2,3] 孙润广 杨富社[1,2,3] 田浩[1,2,3] 肖团利[1,2,3] 雷红茹[1,2,3] 贾永红 崔雄华 李锋[1,2,3] 

机构地区：[1]陕西师范大学实验中心 [2]西安公路交通大学基础课部 [3]西安体育学院附设竞技学校

出　　处：《陕西师大学报（自然科学版）》1998年第2期57-61,共5页Journal of Shaanxi Normal University(Natural Science Edition)

基　　金：国家自然科学基金

摘　　要：用Ｘ射线衍射技术研究抗癌新药顺二氯二氨合铂的结构，讨论了反应机理．实验测得顺二氯二氨合铂属单斜晶系，晶格常数为ａ＝０．９２２１ｎｍ，ｂ＝０．８７７１ｎｍ，间面角α＝γ＝９０°，β＝９７°２５′，轴比Ａ＝ａ／ｂ＝１．０５１３，Ｃ＝ｃ／ｂ＝０．７８５５，单胞中化学式单位数Ｚ＝４，测得的密度ＤＸ＝３．５０９，空间点群Ｐｍ．This article presents the results of the research using the method of X ray diffraction to investigate the characteristics, structures and relation between structures and effect of the platinum anticancer complexa. Experiments show the following: The structure of cisdichlorodiamminoplatinum is monoclinic system. Lattice parameter are a=0.922 1 nm, b=0.877 1 nm, c=0.689 0 nm, α=γ=90°,β=97°25′. Axial ratio are A=a/b=1.051 3, C=c/b=0.785 5. The unit number of chemical formula in the unit cell is Z=4. The density by the method of X ray diffraction is DX=3.509. Space group is Pm.

关 键 词：X射线衍射 顺二氯二氨合铂 晶体结构 抗癌药 

分 类 号：R979.1[医药卫生—药品]