国外药物靶标开发的规律与特点分析  

Characteristic and regular patterns in exploration of drug targets abroad

作　　者：张音[1] 王松俊[1] 刁天喜[1] 楼铁柱[1] 

机构地区：[1]军事医学科学院卫生勤务与医学情报研究所,北京100850

出　　处：《军事医学科学院院刊》2009年第2期166-169,共4页Bulletin of the Academy of Military Medical Sciences

基　　金：国家"863"计划资助项目(No.2006AA02Z316)

摘　　要：随着人类基因组计划的完成、基因功能的发现，以及各种高通量筛选方法的实现，药物靶标已经成为现代创新药物研发的一个重要环节。尽管如此，药物靶标的创新速率仍然维持在非常低的水平上，每年成功上市药物的分子靶标仅有3—5个是新靶标。分析国外药物靶标的开发特点和内在规律，可以为我国生物制药公司和研发机构选择合适的药物靶标提供一些有用的信息。With the completion of Human Genome Project, the discovery of gene function, and the achievement of various high-throughput screening methods, drug targets have become very important in R ＆ D of modern drugs. However, the number of innovated new drug targets have remained very small over the past years, only three to five per year. Knowledge of characteristics and regular pattern in exploration of drug targets will provide us valuable information for target selection.

关 键 词：药物靶标 特点 内在规律 

分 类 号：R91[医药卫生—药学]