我国部分地区未治疗HIV感染人群的病毒载量趋势分析  

The trend of viral load in untreated HIV infectors in some regions of China

作　　者：赵全壁[1] 邢辉[1] 马鹏飞[1] 全宇[1] 冯毅[1] 彭虹[1] 阮玉华[1] 邵一鸣 

机构地区：[1]中国疾病预防控制中心性病艾滋病预防控制中心传染病预防控制国家重点实验室,北京100050

出　　处：《中国艾滋病性病》2009年第2期105-108,共4页Chinese Journal of Aids & STD

基　　金：国家高科技"863"项目(2006AA02Z418);国家重点基础研究发展(973计划;2005CB523103/2005CB522903);第四轮中国全球基金艾滋病项目

摘　　要：目的了解中国艾滋病病毒(HIV)感染者体内病毒载量状况,及病毒载量与临床指征之间的相互关系;为中国艾滋病的预防和抗病毒研究提供基础数据。方法回顾性分析中国2003-2005年间检测的HIV感染者的病毒载量和CD4计数等数据,用SAS9.1进行统计分析,非参数检验。结果中国未治疗的HIV感染人群其病毒载量的最大浓度区域,2005年为104-105拷贝/ml,浓度从2003年的11.2%,2004年19.7%上升到2005年33.6%。中国未治疗的HIV感染人群的病毒载量随着CD4数的升高而减小,病毒载量的中位数,CD4<200时为5.16lg/ml,CD4>500时为2.77lg/ml(P<0.0001)。未治疗组男性病人的病毒载量中位数为4.52lg/ml,高于女性的3.84lg/ml(P<0.0005),差异有统计学意义。结论病毒载量是监测HIV感染者的病程,评估抗病毒治疗的重要指标。中国未治疗的HIV感染人群的病毒载量呈现逐年上升的趋势,应尽早开展抗病毒治疗。Objective To study HIV-1 plasma viral load（VL）status in HIV-1 infectors and correlation between VL and clinical markers. Methods Plasma viral load and CD4^＋ T count of HIV-1 infected subjects tested in 2003 - 2005 were retrospectively analyzed.Results In 2003 11.2% of untreated HIV-1 subjects had viral load ranging 104 - 105 copies/ML, while in 2004 and 2005 the percentage of untreated subjects having such viral load range increased to 19.7 % and 33.6% , respectively. As for HIV-1 infected people receiving antiretroviral drug treatment, 55.6% and 59.8% of them had viral load less than 1000 copies/ml in 2004 and 2005, respectively. An inverse correlation was observed between plasma viral load and CD4^＋ T-cell count among untreated HIV-1 subjects; i.e.viral loads decreased with rising CD4^＋ count. The median viral load was 5. 161g/ml when CD4^ ＋ count was less than 200/ul, and dropped to 2. 771g/ml when CD4^ ＋ count was higher than 500/ul（P〈0. 0001） ;the difference had statistical significance. The median viral load of untreated male subjects was significantly higher than female ones（4. 521g/ml in male vs 3. 841g/ml in female, P〈0. 0005） . Conclusion Viral load and CD4^＋ T-cell count are useful indicators for evaluating AIDS prognosis and antiviral treatment in HIV-1 infectors. Viral load tends to increase year by year among untreated HIV infectors in China and so antiretroviral therapy should be provided for them as early as possible.

关 键 词：艾滋病病毒 病毒载量 逆转录-聚合酶链反应 

分 类 号：R512.91[医药卫生—内科学]