灯盏花素自微乳在大鼠肠道吸收动力学研究  

Study on the Intestinal Absorption of Breviscapine Self-emulsion in Rats

作　　者：张新勇[1] 张兴德[1] 高运军[2] 刘幸平[1] 

机构地区：[1]南京中医药大学药学院,210046 [2]南京市中医院中医药研究所,210001

出　　处：《医药导报》2009年第5期571-573,共3页Herald of Medicine

基　　金：南京市卫生局基金(基金编号:YKK-06123)

摘　　要：目的研究灯盏花素自微乳在大鼠肠道吸收的动力学特征。方法建立大鼠在体肠循环模型,采用酚红标记校正肠循环液体积,以比色法和高效液相色谱法分别测定循环液中酚红和灯盏花素的含量。结果灯盏花素自微乳在药物浓度为20,40,80μg.mL-1时,Ka基本保持不变;不同肠段肠循环液中灯盏花素的剩余量的对数值与时间成线性关系,且不同肠段灯盏花素的吸收速率差异无显著性。结论灯盏花素自微乳在小肠吸收呈一级动力学过程,吸收机制为被动扩散,并且在小肠中无特定吸收部位。Objective To study the intestinal absorption kinetics of breviseapine serf-emulsions. Methods Establishing the in situ perfusion model in rats, and adjusting the volume of perfusion fluid by phenolsulfonphthalein. The contents of phenolsulfonphthalein and Breviscapine of perfusion fluid were detected by using chromatometry and HPLC. Results Ka remained invariant as Breviscapine in self-emulsions was at 20,40,80 μg. mL^-1. There was linear relationship of Breviseapine in self-emulsions between logarithm contents of the surplus in different zone of bowel and time. Meanwhile, the rate of absorption in different zone of bowel showed no significant differences. Conclusion The absorption of Breviscapine selfemulsions in small intestine is a first-order process. The mechanism of absorption is a passive diffusion wihtout specific site.

关 键 词：灯盏花素 自微乳 在体肠循环法 酚红标记 

分 类 号：R286[医药卫生—中药学] R965[医药卫生—中医学]