胰岛素持续皮下输注对2型糖尿病并高脂血症60例临床疗效观察  

Therapeutic observation of continuous subcutaneous insulin infusion in type 2 diabetes and hyperlipidemia in 60 cases

作　　者：王生龙[1] 

机构地区：[1]安阳市第二人民医院,河南安阳455000

出　　处：《医学信息（内.外科版）》2009年第3期210-211,217,共3页Medical Information Operations Sciences Fascicule

摘　　要：目的观察胰岛素持续皮下输注对2型糖尿病并高脂血症临床疗效。方法对60例2型糖尿病并高脂血症患者使用胰岛素泵治疗前后血糖、血脂、C肽(CP)等生化指标的变化。结果治疗前后空腹及餐后2h血糖(FPG及2 hPG)、低密度脂蛋白胆固醇(LDL-C)、甘油三脂(TG)均较治疗前明显降低(P<0.01),血清总胆固醇(TC)降低明显(P<0.05),高密度脂蛋白胆固醇(HDL-C)升高明显(P<0.05),胰岛β细胞功能在治疗后获得改善明显(P<0.05)。结论2型糖尿病合并高血脂的患者采取胰岛素泵强化治疗可以快速稳定控制血糖、改善脂质代谢和显著改善胰岛β细胞功能。Objective To observe the clinical efficacy of continuous subcutaneous insulin infusion in type 2 diabetes and hyperlipidemia. Methods Sixty cases of type 2 diabetes and hyperlipidemia in patients with insulin pump therapy before and after the blood glucose, blood lipids, C - peptide （CP） and other biochemical markers. Results Blood glucose before and after treatment fasting and 2 h postprandial （FPG and 2 hPG） ,low -density lipoprotein cholesterol （LDL- C）, triglyceride （TG） were significantly lower than before treatment （P 〈 O. O1 ）; serum total cholesterol （ TC ） significantly reduced （ P 〈 0. 05 ）, high density lipoprotein cholesterol （ HDL - C ） increased significantly （ P 〈 0. 05 ）, and pancreatic β - cell function improved significantly after treatment （P 〈 0.05 ）. Conclusions Type 2 diabetic patients with high blood lipid of patients to take insulin pump therapy to control blood sugar can quickly stabilize and improve lipid metabolism and marked improvement in islet β -cell function.

关 键 词：2型糖尿病 胰岛素泵 血糖 高脂血症 

分 类 号：R587.1[医药卫生—内分泌]