丙种球蛋白与血浆置换治疗重症肌无力的疗效比较  

Comparison of the efficacy of intravenous immunoglobulin and plasmapheresis in patients with myasthenia gravis

作　　者：郝同琴[1] 李闯[1] 刘建萍[2] 

机构地区：[1]新乡医学院第一附属医院急诊科,河南卫辉453100 [2]新乡医学院第三附属医院

出　　处：《医学信息（内.外科版）》2009年第3期212-214,共3页Medical Information Operations Sciences Fascicule

摘　　要：目的比较血浆置换与丙种球蛋白两种方法治疗重症肌无力(MG)的临床疗效。方法回顾性分析29例MG患者的临床资料,其中16例(A组)进行丙种球蛋白治疗,13例(B组)进行血浆置换治疗,ELISA法检测29例MG患者治疗前后血清乙酰胆碱受体抗体(AchRAb)变化情况,采用临床绝对和相对评分法评价治疗1周后疗效。结果ELISA法检测结果表明两种治疗方法均能使MG患者血浆AchRAb水平明显下调,丙种球蛋白组治疗后AchRAb水平下调至(0.71±0.25)nmol/L,有效率为87.5%;血浆置换组AchRAb水平下调至(0.67±0.27)nmol/L,有效率为92.3%,均有统计学意义(P<0.01),但两种治疗方法之间尚无明显差异(P>0.01)。结论丙种球蛋白与血浆置换治疗重症肌无力疗效确切,两者之间无明显差异性。Objective To compare the efficacy of intravenous immunoglobulin and plasmapheresis on myasthenia gravis. Methods The clinical data of 29 patients with myasthenia gravis were analyzed retrospeeticively, and the patients were diveded into Group A（ 16 cases undergoing intravenous immunoglobulin） and Group B（ 13 cases undergoing plasmapheresis ）. The difference of serum concentration of AchRAb was detected by ELSIA before and after treatment one week. and the efficacy was evaluated by relative clinical score. Results The level of serum concentration of AchRAb was decreased significant after treatment one week, in Group A （0.71 ± 0.25） nmol/L and Group B （0.67± 0.27 ） nmol/L （ P 〈 0.01 ）. The rate of effectiveness was 87.5% and 92.3% （ in Group of undergoing intravenous immunoglobulin and undergoing plasmapheresis ） respectively, but there was no difference between the two groups. Condusions The methods of intravenous immunoglobulin and undergoing plasmapheresis have proven to be effective in treating myasthenia gravis, while there was no difference between the two methods.

关 键 词：重症肌无力 免疫球蛋白 血浆置换 乙酰胆碱受体抗体 

分 类 号：R6[医药卫生—外科学]