临床表现为假性湿疣的高危型HPV感染  

High-risk human papillomaviral infection characterized by pseudocondyloma of vulvae

作　　者：徐娟[1] 王京[1] 陆学东[2] 贺勤 陈加媛 向丽[1] 黄夏萌 

机构地区：[1]广东省深圳市第四人民医院皮肤科,518033 [2]广东省深圳市第四人民医院检验科,518033

出　　处：《中华皮肤科杂志》2009年第5期303-304,共2页Chinese Journal of Dermatology

摘　　要：目的探讨12例临床表现酷似假性湿疣的HPV感染的临床及HPV分型特点。方法检测12例有非婚性接触史临床表现为外阴假性湿疣的女患者，以反向杂交法检测活检或局部刮除物中HPV核酸扩增并分型。结果12例HPV全部阳性，12例患者中共查出13种HPV亚型，其中3种低危型11、42、43，10种高危型16、18、31、33、35、39、51、52、58、59。每例患者至少有1种以上高危HPV亚型。4例患者为1种HPV亚型的感染，6例患者为2种HPV亚型的感染，另有两例分别有3或4种HPV亚型的感染。结论在临床表现为假性湿疣患者中有可能包含高危型HPV的感染。Objective To investigate the clinical features and human papillomavirus （HPV） types in 12 cases of HPV infection characterized by pseudocondyloma of vulvae. Methods Twelve women, who had a history of sexual behavior with non-spouses and presented with pseudocondyloma of vulvae, were included in this study. Tissue specimens were scraped or resected from the lesions of pseudocondyloma of vulvae. PCR-based reverse hybridization assay was performed to determine the genotypes of HPV. Results All the 12 specimens were HPV positive. The reverse hybridization assay generated 13 subgenotypes of HPV, including 3 low-risk genotypes （11, 42 and 43） and 10 high-risk gcnotypes （16, 18, 31, 33, 35, 39, 51, 52, 58 and 59）. All the patients were found to be infected by at least one high-risk genotype. Of the 12 patients, 4 were infected by single type of HPV, 6 by 2 types of HPV, and 2 by 3 or 4 genotypcs of HPV. Conclusion The patients characterized by pseudocondyloma of vulvae may suffer from high-risk HPV infection.

关 键 词：假性湿疣 尖锐湿疣 人乳头瘤病毒 

分 类 号：R752.53[医药卫生—皮肤病学与性病学]