大鼠口服朱砂的唾液与血液及组织汞浓度的相关关系  

Correlations of mercury between saliva and blood or tissue after oral administration of cinnabar to rats

作　　者：丁国华[1] 杨堃[2] 李秀芳[2] 孙艳[1] 陈丽平[1] 李秋红[2] 吴永会[3] 猪爪信夫 

机构地区：[1]中国黑龙江省第二医院暨黑龙江省中毒抢救治疗中心,黑龙江哈尔滨150010 [2]中国黑龙江中医药大学,黑龙江哈尔滨150040 [3]中国哈尔滨医科大学,黑龙江哈尔滨150081 [4]日本国北海道蕖科大学,日本北海道小樽047-264

出　　处：《中国医院药学杂志》2009年第9期709-712,共4页Chinese Journal of Hospital Pharmacy

基　　金：黑龙江省科技攻关课题(编号:2004G0916-00)

摘　　要：目的:建立唾液中汞的检测方法,明确大鼠连续大剂量给予朱砂后唾液与血液、组织间汞浓度的相关关系。方法:大鼠连续口服朱砂(7.0g·kg-1)2～10d后采集血液、唾液、心、肝、肺、肾、脑等样品,原子荧光光谱法测定各样品中的汞浓度,线性回归法计算唾液中汞与血液及各组织间的相关关系。结果:汞在大鼠唾液中有一定分布,大鼠腮腺及颌下腺唾液中汞浓度与唾液/血液浓度(S/B)比、唾液/组织浓度(S/T)比之间的相关关系均良好。结论:通过测定唾液中汞浓度,可以了解血液及组织中汞的分布情况,为重金属中毒的预防、诊断和治疗提供了新的思路和切实可行的测定方法。OBJECTIVE To establish detection method of mercury in saliva and identify the correlations of Mercury between saliva and blood （or tissue） after successive large dose oral administration of Cinnabar to rats. METHODS Each rat was given with a 7. 0 g·kg^-1 dose of Cinnabar by mouth lasted 10 days, biological samples of the rats were collected. Atomic fluorescence spectrometry was used to determine the concentrations of Mercury in biological samples and find out correlations of mercury between saliva and blood （or tissue） after oral administration of cinnabar to rats. RESULTS Mercury was detected in saliva. The correlations between saliva and S/B ratio, saliva and S/T ratio were good. CONCLUSION These results suggested blood and tissue level of mercury could be learnt by measuring the concentration of mercury in saliva. These studies provided a practical approach to the determination for the heavy metal poisoning diagnosis, prevention and treatment.

关 键 词：汞 朱砂 唾液 全血 组织 相关关系 

分 类 号：R961[医药卫生—药理学]