海水和淡水肺内灌注对兔肺损伤作用的实验观察  

Effects of seawater and freshwater perfusion on lung injury in rabbits

作　　者：韩志海[1] 段蕴铀[1] 刘于红 冯华松[1] 

机构地区：[1]海军总医院呼吸科,北京100048 [2]海军总医院 重症监护室,北京100048

出　　处：《中华航海医学与高气压医学杂志》2009年第2期71-74,共4页Chinese Journal of Nautical Medicine and Hyperbaric Medicine

基　　金：基金项目：海后司令部科研计划课题（06-3305）

摘　　要：目的观察海水和淡水肺内灌注引起兔肺损伤情况的异同。方法21只新西兰兔随机分为正常组、海水灌注组和淡水灌注组，将等量海水和淡水通过气管插管灌入兔肺内，3h后观察兔在症状学、血气分析、血液动力学、肺损伤指标、组织学等方面的变化，并将上述指标进行统计学处理，观察肺组织损伤程度的异同。结果血气分析、炎症因子检测、肺组织学损伤评分结果显示，等量海水和淡水灌注均可在一定程度上对实验兔的肺组织造成损伤，且海水灌注对肺组织的损伤要重于淡水灌注（P〈0．05）。结论海水肺内灌注造成的肺组织损伤重于淡水灌注。Objective To investigate differences in lung injury induced by seawater and freshwater perfusion in rabbits. Methods 21 New Zealand rabbits were randomly divided into the normal group （the control group）, the freshwater group and the seawater group. Same amounts of seawater and freshwater were perfused in the lungs of rabbits through tracheal incubation. Changes in the indices concerning symptomatology, blood-gas, hemodynamics, tumor necrosis factor （TNF-α） , interleukin 6 （IL-6）, histology and lung injury were monitored 3 hours later. Then, the obtained data were analyzed statistically to see the differences in lung lesions of different animal groups. Results Blood-gas analysis, inflammatory factor measurement, lung injury score indicated that seawater and freshwater perfusion could all induce lung injury to a certain extent, and the injury induced by seawater perfusion was obviously severer（ P 〈0.05 ）. Conclusions Lung injury induced by seawater perfusion is severer than that by freshwater perfusion.

关 键 词：海水灌注 淡水灌注 肺损伤 

分 类 号：R686[医药卫生—骨科学]