78例双黄连注射液不良反应报告分析  

Adverse Drug Reactions Induced by Shuanghuanglian Injections:Analysis of 78 Cases

作　　者：肖若媚[1] 范治国 王琦[3] 覃正碧[4] 

机构地区：[1]中山市人民医院,中山市528403 [2]重庆北部新区高新园人民医院,重庆市401121 [3]天津市药品不良反应监测中心,天津市300070 [4]华中科技大学同济医学院,武汉市430003

出　　处：《中国药房》2009年第14期1107-1109,共3页China Pharmacy

摘　　要：目的:了解双黄连注射液不良反应的发生规律,提高其临床安全、合理应用水平。方法:分析天津市药品不良反应监测中心数据库收集到的78例双黄连注射液不良反应报告,从患者的一般情况、不良反应累及系统或器官与临床表现、用药情况等方面进行统计、分析。结果:双黄连注射液引起不良反应的临床表现主要为皮肤及其附件损害等。引发不良反应的原因主要涉及药物本身成分、配伍不当等因素。结论:应规范生产工艺,对儿童及老年患者应注意剂量,并注意在与其它药物合用时应避免配伍禁忌。OBJECTIVE： To discuss the regular patter of the occurrence of adverse drug reactions（ADR） induced by Shuangjhuanglian Injection and to improve the knowledge on the safe and rational use of this kind of drug in the clinic. METHODS： A total of 78 ADR cases induced by Shuanghuanglian Injections in the database of Tianjin ADR monitoring center were analyzed statistically in respect of patients＇ general data, systems or organs involved and the clinical manifestations and medication etc. RESULTS： The main adverse drug reactions caused by Shuanghuanglian Injections presented as lesions of skin and its appendants. And the ADR were chiefly resulted from the drugs（Shuanghuanglian Injections） themselves or the incompatibility etc. CONCLUSION： It is necessary to standardize the preparation technology of Shuanghuanglian Injections and attach great importance to the dosage of Shuanghuanglian Injections for children and aged patients and the imcompatibility when used in combination with other drugs.

关 键 词：双黄连注射液 不良反应分析 合理应用 

分 类 号：R969.3[医药卫生—药理学] R283.611[医药卫生—药学]