软脉灵对大鼠糖尿病性白内障晶状体抗氧化的影响  

Antioxidation Effets of Ruan-ma-iling in Lens of Diabetic Cataract (DC) rats

作　　者：陈金雄[1] 徐国兴[2] 何青[2] 谢茂松[2] 王婷婷[2] 许清水[3] 

机构地区：[1]福建医科大学附属第一医院中西医结合科,350005 [2]福建省眼科研究所,361005 [3]福建中医学院,350108

出　　处：《光明中医》2009年第5期835-837,共3页GUANGMING JOURNAL OF CHINESE MEDICINE

基　　金：福建省卫生厅中医药科研课题(No:WZY0609)

摘　　要：目的:探讨软脉灵对大鼠糖尿病性白内障(diabetic catara,DC)的作用及其机理。方法:采用链脲佐菌素(STZ)诱发糖尿病性白内障大鼠模型,将SD大鼠随机分成正常组、模型组、软脉灵高、中、低剂量组。造模后治疗组给于软脉灵治疗,连续灌胃12周,观察不同时段晶状体的变化,测定干预后各组大鼠晶状体的超氧化物化酶(SOD)、丙二醛(MDA)含量的影响。结果:正常组晶状体一直保持透明,STZ诱发的糖尿病(diabetes mellitus,DM)大鼠随着造模后病程的延长,晶状体混浊程度进一步加重,而软脉灵组随着剂量的增加晶状体混浊进一步减轻。与模型组比较,软脉灵可降低晶状体的MDA含量,提高SOD活性(P<0.05～0.01)。结论:软脉灵能提高DM大鼠抗氧化能力,减轻晶状体的氧化损伤,从而延缓糖尿病性白内障发生发展。To investigate the effect and the mechanism of Ruan-mai-lin in lens of diabetic cataract rats. Methods： Diabetic cataract model was made by intaperitoneal injection of streptozotocin（STZ）. SD rats were assigned randomly to normal group, model group, high dose Ruan-mai-lin group, medium dose Ruan-mai-lin group, and low dose Ruan-mai-lin group. The DC rats of treatment groups were intragastrically infused with Ruan-mai-lin solution for 12 weeks. The lens opacification was recorded at different times. The levels of SOD and MDA in lens were determined after tretment. R^ults：The lens of normal rats had maintained a good transparency to the end of experiment. Lens opacification of DC rats progressed with the course of disease prolonging, Accompanying dose increase, Ruan-mai-lin decreased Lens opacification of DC rats （ P 〈 0.05 - 0.01 ）. Compared with the mode group, MDA content of the lens in Ruan-mai-lin groups decreased, and SOD activity of the lens in Ruan-mai-lin groups increased. Conclusion： Ruan-mai-lin could reduce oxidative damage of lens in DC rats by enhancing the antioxidant capacity of diabetes mellitus rats, and consequenty delay theoccurrence and development of DC.

关 键 词：软脉灵 糖尿病性白内障 抗氧化 

分 类 号：R285.5[医药卫生—中药学]