南京地区1105例变应性皮肤病患者血清过敏原特异性IgE抗体检测  

Detection of serum specific immunoglobulin E antibodies in 1105 patients with allergic dermatosis in nanjing region

作　　者：蔡秀玲[1] 仇宁[1] 冯素英[1] 李安生[1] 冷欣彦[2] 李小慧[1] 

机构地区：[1]中国医学科学院北京协和医学院皮肤病研究所,南京210042 [2]南京农业大学动物医学院

出　　处：《国际皮肤性病学杂志》2009年第3期135-136,共2页International Journal of Dermatology and Venereology

摘　　要：目的探讨南京地区变态反应性皮肤病患者血清中过敏原特异性IgE抗体水平。方法采用免疫印迹法检测变态反应性皮肤病患者血清中过敏原特异性IgE抗体和总IgE抗体。结果1105例变态反应性皮肤病患者特异性IgE阳性率58．7％（649／1105）。检测的不同变态反应性皮肤病患者血清中过敏原特异性IgE抗体水平在吸人组中以屋尘过敏原特异性IgE抗体检出比例最高达36．83％（407／1105）；其次是户尘螨，达23．26％（257／1105）。在食物组中以腰果过敏原的检测比例最高，达7．33％（81／1105），其次是牛奶，达5．43％（60／1105）。从性别上来看，男女在一些过敏原上差异有统计学意义。从年龄上来看，≤14岁组和〉14岁组在一些过敏原上，经统计分析差异有统计学意义。结论特异性IgE抗体和总IgE检测可以帮助临床寻找相应的过敏原，为变态反应性皮肤病的预防和治疗提供参考。Objective To investigate the level of serum specific immunoglobulin E （ slgE） antibodies in patients with allergic dermatosis in Nanjing region. Methods A total of 1105 patients in Nanjing region with allergic dermatosis, including 625 cases of urticaria, 293 cases of eczema, some cases of atopic dermatitis and other allergic dermatosis, were enrolled in this study, lmmunoblotting test was used to detect serum slgE and total IgE in these subjects. Results The prevalence of slgE was 58.7% （649/1105） in these patients. The most common inhalation allergen was housedust with a prevalence of 36.83% （407/1105）, followed by house dust mites （23.26%, 257/1105）. Among food allergens, the highest positive rate belonged to cashew nut （7.33%, 81/1105）, and the second was milk （5.43%, 60/1105）. Moreover, significant difference was observed in the frequency of sensitization to some allergens between female and male patients and between patients no older than 14 years and those older than 14 years （all P 〈 0.05）. Conclusion Detection of serum slgE and total IgE can help clinicians to find associated allergens, which may provide a basis for the prevention and treatment of common allergic dermatosis.

关 键 词：皮肤疾病 超敏反应 变应原 SIGE 

分 类 号：R758.2[医药卫生—皮肤病学与性病学]