代谢水平渐变时微循环调节模拟系统的研究  

Simulation System of Microcirculation Metabolic Regulation at Low Levels

作　　者：宋江超[1,2] 谢敏[3] 刘辉凤[3] 伍冬平[3] 白伦[3] 

机构地区：[1]中国农业科学院蚕业研究所,江苏镇江212018 [2]农业部蚕桑产业产品质量监督检验测试中心,江苏镇江212018 [3]苏州大学纺织与服装工程学院,江苏苏州215021

出　　处：《现代生物医学进展》2009年第9期1624-1627,共4页Progress in Modern Biomedicine

基　　金："十一五"国家重点基础研究发展计划"组织诱导性生物医用材料的基础研究"子项目"天然丝素蛋白基材料及其组织诱导功能的构建(课题编号:2005CB623906)"的资助

摘　　要：目的:构建组织代谢水平渐变条件下的微循环调节动态过程模拟系统,进行毛细血管系统代谢性调节的理论研究。方法:利用计算机编程构建代谢水平渐变条件下的微循环调节动态过程模拟系统,以此分析和研究微循环代谢性调节。结果:讨论了毛细血管单元开放率和开闭频率在代谢性调节过程中的变化等基本问题,并给出了微循环系统对于代谢状态变化快速反应机制的解释。结论:构建了微循环代谢性调节的计算机模拟系统平台方面取得了初步的进展,为进一步深入地分析微循环代谢性调节机制确立了近似的模拟分析方法,进一步为阐明微循环代谢性调节机制奠定了基础,为充分利用微循环代谢性调节作用提供了便捷的工具。Objective： To research microcirculation metabolic regulation, the simulation system of microcirculation regulation was established when the metabolic state changes gradually in a long time. Methods： On the basis of the new theoretical model of micro- circulation metabolic regulation,the simulation system was established by means of computers. Results： Using this simulation system, the open-close state of capillaries, the opening rate as well as switching frequency have been discussed and analyzed, and expatiations of fast mechanism about microcirculation response to metabolic levels have been provided. Conclusions： A preliminary progress on the computer simulation platform of the metabolic regulation of microcirculation has been obtained. In addition, this job affords an approximative simulation method and initial software for further study.

关 键 词：微循环 代谢性调节 毛细血管 血流调节 氧输运 

分 类 号：R331.3[医药卫生—人体生理学]