sICAM-1、sCD40L与糖尿病大血管病变的关系及干预研究  

Relationship between sICAM-1,sCD40L and Diabetic Macroangiopathy and Intervention Study

作　　者：靳瑾[1] 孙侃[1] 薛以贵 常向云[1] 周婷[1] 赵瑾[1] 

机构地区：[1]新疆石河子大学医学院第一附属医院,新疆石河子832002 [2]西安陆军学院军医训练大队,新疆昌吉831200

出　　处：《现代生物医学进展》2009年第9期1641-1644,共4页Progress in Modern Biomedicine

基　　金：石河子大学科技资金资助项目(ZRKX2006-Y10)

摘　　要：目的:观察sICAM-1、sCD40L与糖尿病大血管病变的关系,辛伐他汀干预后对sICAM-1、sCD40L水平变化和糖尿病大血管病变发生、发展的影响。方法:复制糖尿病合并大血管病变大鼠模型,随机分为正常对照组(A组)、正常干预组(B组)、糖尿病对照组(C组)、糖尿病干预组(D组),B组和D组给予辛伐他汀灌胃,A组和C组灌予相应量的生理盐水,8周末测四组血生化指标、血清sICAM-1和sCD40L,留取主动脉观察病理变化。结果:血糖C组和D组相近,均显著高于A组和B组(P<0.01);总胆固醇(TC)、甘油三酯(TG)及低密度脂蛋白(LDL-C)A组高于B组,C组高于D组;C组sICAM-1、sCD40L显著高于A组、B组和D组(P<0.01),D组明显低于C组(P<0.01);光镜下观察胸主动脉病变D组较C组减轻,A组与B组相比无明显变化。结论:sICAM-1、sCD40L与糖尿病大血管病变的发生有关;辛伐他汀干预治疗能够降低sICAM-1、sCD40L的水平,同时有明显延缓糖尿病大血管病变的作用。Objective： To observe the relationship between sICAM-I,sCD40L and diabetic macroangiopathy, the Simvastatin intervention effects on the level of sICAM-1,sCD40L and diabetic macroangiopathy development. Methods： Duplicate diabetic and macroangiopathy rat model, randomly divide the rats into normal control group （ group A）, normal intervention group （ group B）, diabetic normal group （group C） and diabetic intervention group （ group D）. Simvastatin was taken for group B and D; group A and B were treated with corresponding sodium chloride. At the end of 8th week, test biochemical indicators, sICAM-1 and sCD40L; obtain the thoracic aorta to observe pathological changes. Results： Blood glucose levels in group C were similar to those in group D, which were higher than those in groupA and B （P〈0.01）; total cholesterol, triglyceride and low density lipoprotein in group A were much higher than those in group B; group C higher than group D; sICAM-1, sCD40L in group C were much higher than those in group A, B and D （P〈0.01）; group D were much lower than those in group C （P〈0.01）; the aorta thoracalis pathological changes by light microscope show that group D more extenuation than group C. Conclusions： sICAM-1 and sCD40L relate to diabetic macroangiopathy occurrence. Simvastatin can decrease the sICAM-1 and sCD40L levels and delay diabetic macroangiopathy obviously.

关 键 词：糖尿病 细胞间粘附分子-1 可溶性白细胞表面分化抗原CD40L 大血管病变 辛伐他汀 

分 类 号：R587.1[医药卫生—内分泌]