正常小型家猪脑血流灌注特征的SPECT/CT研究  

Study on SPECT/CT Imaging in Cerebral Blood Perfusion of Normal Mini-pigs

作　　者：赵雁[1] 王飞[2] 黄钢[1] 

机构地区：[1]上海交通大学医学院附属仁济医院核医学科,上海2000127 [2]上海交通大学医学院附属仁济医院神经外科,上海2000127

出　　处：《现代生物医学进展》2009年第9期1707-1709,共3页Progress in Modern Biomedicine

基　　金：上海市教委科研项目资助(No.07ZZ34);上海市重点学科建设项目资助(No.S30203)

摘　　要：目的:探讨采用SPECT/CT获得小型家猪脑血流灌注特征的方法和可行性。方法:对8头健康小型家猪进行SPECT/CT脑显像,进行图像预处理,自动提取脑相同感兴趣的相对血流量和相对离散度。结果:正常小猪脑不同感兴趣区相对血流量存在较大差异(P<0.05),相对脑血流量值以颞顶叶最高,其次是额顶叶,小脑最低。正常小猪脑各感兴趣内的相对离散度有统计学差异(P<0.05),相对离散度小脑感兴趣区最高,额叶感兴趣区最低。结论:SPECT/CT可用于半定量评价小型家猪脑血流灌注。Objective： To explore the feasibility of exploring the cerebral blood flow perfusion characteristics in normal mini-pigs by SPECT/CT imaging. Methods： SPECT/CT scans were performed in 8 normal mini-pigs, and their raw images were preprocessed. The relative dispersion and the relative cerebral blood flow of same ROIs （region of interest） were abstracted. Results： SPECT/CT scans of normal mini-pigs were feasible. Cerebral blood flow differences were found in different regions （P〈0.05）： that of the cortexes were the highest, and next was that of the temporoparietal and occipitoparietal region, and the cerebellum region was the lowest. The relative dis- persion of different regions was also statistically different. That of the cerebellum region was the highest and the frontal region was the lowest. Conclusions： SPECT/CT can be used to estimate the cerebral blood flow perfusion characteristics in normal mini-pigs.

关 键 词：SPECT/CT 脑血流灌注 

分 类 号：R817.1[医药卫生—影像医学与核医学]