3-取代-5-芳基噁唑-4-酮类化合物的合成与生物活性  

Synthesis and Biological Activities of 3-Substituent-5-aryloxazolidin-4-ones

作　　者：姚红伟[1] 李欢欢[1] 苏娜娜[1] 王红学[1] 刘幸海[1] 王力钟[1] 张晓[1] 李正名[1] 赵卫光[1] 

机构地区：[1]南开大学元素有机化学国家重点实验室,农药国家工程中心,天津300071

出　　处：《高等学校化学学报》2009年第5期908-912,共5页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:20772069)资助

摘　　要：以香草醛和取代扁桃酸为原料,经多步反应合成了N-取代苯乙基扁桃酰胺,在对甲苯磺酸催化下,和醛脱水关环,得到一系列新颖的3-取代苯乙基-5-芳基噁唑-4-酮类化合物和N-扁桃酰四氢异喹啉类化合物.所有化合物通过红外光谱、核磁共振氢谱、元素分析和高分辨质谱对其结构进行表征,并对其构效关系进行了讨论.Mandipropamid is the first mandelamide fungicide on the market. Cyclizing open structures in a given structure represents one of the useful methods in the search for biologically active conformations. A series of novel 3-substituentphenethyl-5-aryloxazolidin-4-ones, the ring-closed analogues of mandipropamid, were obtained from the 2-hydroxy-N-（ substitutedphenethyl ）-2-arylacetamide and aldehydes by refluxing in benzene or toluene with catalytic amount of p-toluenesulphonic acid. Their structures were identified by means of elemental analysis, IR, ^1H NMR and MS spectra. And their structure-activity relationships were discussed.

关 键 词：噁唑酮 扁桃酰胺 生物活性 

分 类 号：O626[理学—有机化学]