新型β,β-桥连双卟啉的合成及其光敏活性研究  

Synthesis of Novel β,β-Bridged Porphyrin Dimers and Investigation of Their Photosensitive Activity

作　　者：黄齐茂[1] 肖欣[1] 潘志权[1] 李志远[1] 邓鹏星[1] 章颖[1] 

机构地区：[1]武汉工程大学绿色化工过程省部共建教育部重点实验室,武汉430073

出　　处：《高等学校化学学报》2009年第5期923-927,共5页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:20471045);湖北省自然科学基金杰出人才项目(批准号:2008CDB072)资助

摘　　要：以1,6-二溴己烷为桥连试剂,2-(1-羟基萘基)-5,10,15,20-四苯基卟啉及其Cu(Ⅱ),Ni(Ⅱ),Zn(Ⅱ)配合物为原料,合成了4个新型β,β-桥连双卟啉.以1,3-二苯基异苯并呋喃(DPBF)为猝灭剂,测试了双卟啉及其Ni(Ⅱ),Zn(Ⅱ)配合物在光照条件下产生单线态氧的能力,并研究了4个双卟啉化合物在光照和无光照条件下对pBR322质粒DNA的切割能力(用凝胶电泳)和对金黄色葡萄球菌(ATCC 25923)的光敏抑菌活性.结果表明,新型双卟啉光敏剂具有较好光敏活性,产生的活性氧能有效杀灭金黄色葡萄球菌.Four novel β,β-bridged porphyrin dimers were designed and synthesized. The monomers are 2-（ 1- hydroxynaphthyl）-5,10,15,20-tetraphenylporphyrin or its Cu（ Ⅱ ）, Ni（ Ⅱ）, Zn（ Ⅱ） complexes. The abilities of singlet oxygen production for the porphyrin dimer and its Ni （ Ⅱ） , Zn （ Ⅱ ） complexes under photo irradiation were studied with DPBF as the quencher. The cleavage ability of pBR322 DNA （by gel electrophoresis） and antibacterial activity on Staphylococcus aureus （ATCC 25923 ） of the novel porphyrin dimers were tested under photo irradiation and in dark. The results show that porphyrin dimers exhibit high photocytotoxicity against Staphylococcus aureus.

关 键 词：双卟啉 pBR322质粒DNA 抗菌 光敏活性 

分 类 号：O625.6[理学—有机化学]