海马硬化的扩散张量成像参数值变化初步研究  

Preliminary study on diffusion tensor imaging parameters in hippocampal sclerosis

作　　者：贾策[1] 张泉[1] 冯凯琳[1] 

机构地区：[1]武警医学院附属医院放射科,天津300162

出　　处：《武警医学院学报》2009年第4期304-307,共4页Acta Academiae Medicinae CPAPF

摘　　要：【目的】探讨海马硬化(HS)患者的扩散张量成像(DTI)参数值变化特点,初步评价DTI在海马硬化术前诊断中的价值。【方法】对11例单侧海马硬化患者和32例健康志愿者行常规MRI和DTI检查,定量测量双侧海马的平均扩散系数(DCavg)、部分各向异性(FA)、1-容积比(1-VR)和相对各向异性(RA)值并统计。【结果】常规MRI:7例左侧海马硬化,4例右侧海马硬化,无双侧海马萎缩、硬化。正常人双侧海马之间DCavg、FA、1-VR和RA均无显著性差异。海马硬化患者:患侧海马DCavg显著高于对侧海马和正常人,患侧海马FA、1-VR和RA低于对侧海马和正常人。【结论】海马硬化的DTI参数值变化具有一定特征性,DCavg升高、FA、1-VR、RA减低能够作为诊断海马硬化的有用指标。To investigate the diffusion characteristics of hippocampi in patients with hippocampal sclerosis and to study the value of diffusion tensor imaging （DTI） in preoperative diagnosisof hippocampal sclerosis. [Methods] Eleven patients of unilateral hippocampal sclerosis and 32 healthy volunteers received conventional and DTI scanning. The DCavg, FA, 1-VR and RA of bilateral hippocampi were measured respectively. [Results] On conventional images, 7 of 11 cases had fight hippocampal pathology, and 4 of 11 cases had left hippocampal pathology. There were no bilateral hippocampal atrophy. No significant differences of DCavg, FA, 1-VR and RA were noted between right and left hippocampi in the controls.The DCavg of ipsilateral hippecampi was higher than contralateral side and healthy controls. The FA, 1-VR, RA of ipsilateral hippocampi were lower than contralateral side and healthy controls. [Conclusions] DTI parameters of hippocampal sclerosis was characteristic and the increased DCavg, decreased FA, 1-VR and RA could be used as an useful index of diagnosing hippocampal sclerosis.

关 键 词：海马硬化 磁共振成像 扩散张量成像 

分 类 号：R81[医药卫生—放射医学]