女性HIV感染者甲状腺功能与性激素水平的研究  

Research on thyroid and level of sexual hormone of females with HIV infected

作　　者：柯亭羽[1] 杜娟[1] 潘毅[1] 周洪[1] 王玉 洪立珠 袁卫红[3] 徐勉[1] 

机构地区：[1]昆明医学院第二附属医院老年内分泌科,650101 [2]云南省艾滋病关爱中心,昆明650101 [3]昆明医学院第二附属医院核医学科,650101

出　　处：《国际生物医学工程杂志》2009年第2期85-87,共3页International Journal of Biomedical Engineering

基　　金：云南省教育厅科研基金项目（520298C）

摘　　要：目的研究人类免疫缺陷病毒（HIV）感染的女性患者是否存在甲状腺功能障碍及性激素水平变化，观察甲状腺激素变化与性激素变化之间的关系。方法采用放射免疫法测定研究对象的甲状腺激素及性激素，分析2者间的相关性。结果34％的患者出现一种或多种甲状腺激素的改变．19％的发生亚临床甲减；睾酮（T）、雌激素（E2）、孕酮（P）、泌乳素（PRL）改变差异显著（P〈0．05）；甲状腺激素值有变化的患者比甲状腺激素值无变化的患者T下降更明显（P〈0．05）。结论HIV感染女性患者存在甲状腺激素的紊乱；HIV感染女性患者存在性激素的紊乱；存在甲状腺激素紊乱的HIV感染女性患者性激素紊乱更明显。Objective To investigate the possible occurrence of thyroid dysfunction and changes of sexual hormone level in human immunodeficiency virus （HIV） infected females, and to observe the correlation between changes of thyroid hormone and sexual hormone. Methods thyroid hormone and sexual hormone of patients were determined by radioimmunoassay and the correlation between them was tested. Results As many as 34% of the patients had one or more changes in thyroid hormone and 19% of the patients had the occurrence of subclinical hypothyroidism. There were significant changes in T, E2 P, PRL（P〈0.05） and the patients with thyroid hormone changes had more obvious decrease in T level（P〈0.05）. Conclusion Thyroid hormone disorders and sexual hormone disorders exist in HIV infected female patients. HIV infected females with thyroid hormone disorders showed more significant changes in sexual hormone level.

关 键 词：人类免疫缺陷病毒 获得性免疫缺陷综合征 甲状腺功能 性激素 

分 类 号：R512.91[医药卫生—内科学]