未刺激的未成熟卵体外培养在多囊卵巢综合征患者中的应用  

In vitro maturation and fertilization of unstimulated inmature oocyte for treatment of infertility women withpoly cystic ovary syndrome

作　　者：赵彩岩 梅丽 刘丽 

机构地区：[1]辽宁省沈阳二○四医院,110043

出　　处：《中国实用医药》2009年第13期20-21,共2页China Practical Medicine

摘　　要：目的探讨未刺激的未成熟卵体外培养成熟(IVM)治疗难治性多囊卵巢综合征(PCOS)患者的疗效。方法2005年10月至2006年10月本中心对50例难治性PCOS患者65个周期的IVM治疗。结果9个周期取消,取消率为13.85%;65个周期共获卵1338枚,平均每周期20.6枚,培养48h后总成熟率为68.5%。正常受精率为70.2%,卵裂率为91.1%,每穿刺周期和移植周期的临床妊娠率分别为37.5%和40.6%,28例临床妊娠中,6例多胎,多胎妊娠率为21.4%。结论未经刺激的IVM技术用于难治性PCOS是一种有效的方法,可获得与常规体外受精-胚胎移植(IVF-ET)相似的临床妊娠率。Objective To evaluate the clinical application of in vitro maturation（IVM） of unstimulated inmature oocytein the treatment of infertility women with polycystic ovary syndrome. Methads Between Oct. 2005 and Oct. 2006,65 cycles of IVM in 50 infertility women with obstinate polyeystic otaty syndrome （PCOS） were carried out. Results 9 cycles were cancelled and cancellation rate was 13.85% ;a total of 1338 inmature oocytes were obtained in 65 cycles with the average number of 20. 6 per cycle. A total of 643 oocytes were normally fertilized by ICSI 70. 2%, with a cleavage rate of 91.1%. 28 clinicat pregnancies were obtaind. Pregnancy rate was 37.3% per puncture and 40. 6% per transfer. Among the 28 cases 6 cases were multipregnancy. The muhipregnancy rate were 21.4%. Conclusion Our results shows that IVM of unstimulated in mature oocytes is an effective method for the treatment of infertility women with obstinate PCOS which maybe offered as an ahimative to conventiona IVF.

关 键 词：多囊卵巢综合征 未成熟卵体外培养成熟 体外受精.胚胎移植 

分 类 号：R711.7[医药卫生—妇产科学]