阿托伐他汀钙对系统性红斑狼疮并血脂异常患者血管内皮功能的影响  

Effect of Atorvastatin on Vascular Endothefial Function in Patients of SLE with dyslipidemia

作　　者：林玲[1] 壮可[1] 乌若丹[1] 寿涛[2] 万颖[2] 赵燕[1] 张宏[1] 

机构地区：[1]云南省第一人民医院心内科,650032 [2]云南省第一人民医院风湿免疫科

出　　处：《中国临床实用医学》2009年第5期40-42,共3页China Clinical Practical Medicine

摘　　要：目的探讨系统性红斑狼疮（SLE）合并血脂异常患者血管内皮功能状况以及阿托伐他汀钙对其血脂和血管内皮功能的影响。方法控制影响血管内皮功能因素后纳入观察组的67例SLE合并血脂异常患者，以及年龄、性别匹配的对照组55名，用彩色超声检测两组血管内皮功能加以对比；并予观察组口服阿托伐他汀钙片20mg，1次／a，疗程为十二周。服药后再次超声复查血管内皮功能以及血脂情况，分析阿托伐他汀钙对SLE合并血脂异常患者血脂及血管内皮功能的影响。结果观察组血管内皮功能较对照组明显下降（P〈0．05），服药后较服药前TG、LDL—C、apoB100明显降低（P〈0．05），HDL-C、apoA。明显升高（P〈0．05），血管内皮功能明显改善（P〈0．05）。结论SLE合并血脂代谢异常患者存在血管内皮功能障碍ECD，阿托伐他汀钙可以升高HDL-C，降低LDL-C及TG，调整SLE合并血脂异常患者的ECD，防治SLE患者动脉粥样硬化的发生和发展。Objective To investigate the change of vascular endothelial function （EF）in patients of systemic lupus erythematosus （SLE） with dyslipidemia and the influence of atorvastatin on the EF and plasma lipid. Methods After controlled by other factors that could impair EF, 67 patients of SLE with dyslipidemia were enrolled as observation group（ atorvastatin 20 mg,per night for 12 weeks）and 55 control subjectives were chosen by match-pairing of age and sex. Assessment of EF was performed by color Doppler ultrasound. After treatment, the measurement of plasma lipid and EF were repeated. Results After treatment,the EF of observation group was improved compared with control group（ P 〈 0.05 ）. The plasma TG,LDL-c and apoB100 levels were lower（ P 〈 0. 05 ） , HDL-c and apoA levels were higher（ P 〈 0. 05 ）and the improvement of EF was better in observation group after treatment （ P 〈 0. 05 ）. Conclusion The vascular endothelial function was impaired in patients of SLE with dyslipidemia. Atorvastatin could modify the metabolism of lipid, improve the vascular endothelial function and proteet the patients from the development of atherocleresis.

关 键 词：系统性红斑狼疮 血脂 阿托伐他汀钙 血管内皮功能 

分 类 号：R593[医药卫生—内科学] R589[医药卫生—临床医学]