葡萄糖手性固定相的合成及对手性药物对映体的拆分  

Preparation and evaluation of D—Glucose Bonded Stationary Phase for High Performance Liquid Chromatography

作　　者：赵峰[1] 阿芳[2] 袁黎明[2] 

机构地区：[1]昭通师专化学系,云南昭通657000 [2]云南师范大学化学化工学院,云南昆明650092

出　　处：《云南师范大学学报（自然科学版）》2009年第3期51-55,共5页Journal of Yunnan Normal University:Natural Sciences Edition

基　　金：云南省自然科学基金(批准号:2005E0006Z)资助项目;云南省教育厅课题基金项目(No08c0236)

摘　　要：合成了葡萄糖的键合手性硅胶固定相,通过对葡萄糖手性固定相做热重分析得出了键合成功的结论,并对其高效液相色谱性能进行了考察,结果表明:所拆分的20种手性药物,有13种手性药物能得到基线分离,最好的分离度R s=7.56,拆分效果良好。D-glucose bonded silica stationary phase was prepared. The Conclusion of bonded success is maded by the thermal analysis. The chromat - omatographic Performance of D-glucose bonded silica stationary phase was studied . Thirteen of the twenty chiral drugs could be baseline separated , and the best value of resolution factors （Rs） was 7.56, the results show that the chiral column possess - es a good separation ability to chiral compound.

关 键 词：D-(+)-葡萄糖 手性固定相 合成 高效液相色谱 

分 类 号：O657.7[理学—分析化学]