国产与进口噻氯匹定对血液流变学的影响  

Effects of hemorrheology of domestic and imported ticlopidine-an open paralleled controlled study

作　　者：蔡乃绳[1] 王敏华 周达新[1] 徐水萍 过鑫昌[2] 戚文航[2] 杨菊贤 

机构地区：[1]上海医科大学中山医院心内科,上海市心血管病研究所,上海200032 [2]上海第二医科大学瑞金医院心内科,上海200025 [3]上海市第九人民医院心内科,上海200011

出　　处：《中国临床药学杂志》1998年第1期10-12,共3页Chinese Journal of Clinical Pharmacy

摘　　要：目的:评价国产与进口噻氯匹定(TCP)对60例心脑血管疾病伴有血小板聚集率高的患者血液流变学的影响.方法:采用多中心、开放平行对照.结果:两药均能显著降低血小板聚集率、纤维蛋白原、全血比粘度、血浆比粘度(P<0.01).两药对血小板聚集率、纤维蛋白原、全血比粘度、血浆比粘度在治疗前后的差值无统计学差异(P>0.05).两组治疗后出血、凝血时间比治疗前均有延长,但无统计学差异(P>0.05),两组治疗前后出血、凝血时间的差值经统计学处理无显著差异(P>0.05).国产和进口TCP不良反应发生率分别为22.5%、30%,两者无显著差异.结论:国产与进口TCP同样具有较好的抗血小板聚集作用,且不良反应少,适用于高血小板聚集率的治疗,可用来预防血栓性疾病.AIM : To evaluate the effect of hemorrheology ,domestic ticlopidine (Lixuda) was compared to imported ticlopidine (Ticlid). METHODS: An open paralleled-controlled trial on 60 subjects with high blood pletelet aggregation who suffered from cardiovascular diseases was carried out. RESULTS: Two drugs can decrease blood fibrinogen, vescosity of blood and vescosity of plasma significantly (P < 0. 05 ), but no significances between two drugs(P>0. 05). Two drugs can prolong bleeding time and clotting time,but there were no significances between two drugs. The adverse effect rates of domestic and imported ticlopidine were 22-5% and 30% respectively, and no significances between two drugs (P> 0.05)). CONCLUSION; It shows that domestic ticlopidine has the same effects on blood pletelet aggregation as imported ticlopidine.

关 键 词：噻氯匹定 血液流变学 血小反凝聚 心脑血管疾病 

分 类 号：R543.06[医药卫生—心血管疾病] R558.05[医药卫生—内科学]