长效二氢奎尼丁治疗40例心房纤颤患者的疗效与血药浓度的关系  

The study of relationship between dihydroquinidine serum concentration and effect of treatment for 40 patients with atrial fibrillation

作　　者：苏乐群[1] 李宏建[1] 周聊生[1] 陈明友[1] 

机构地区：[1]山东省千佛山医院,济南250014

出　　处：《中国临床药学杂志》1998年第1期30-33,共4页Chinese Journal of Clinical Pharmacy

摘　　要：目的:观察长效二氢奎尼丁治疗心房纤颤的疗效与血药浓度的关系.方法:10例心房纤颤病人一次po长效二氢奎尼丁,以TDx测定血药浓度.结果:T_(1/2(Ka))=(2.22±1.25)h,T_(1/2)=(8.22±4.25)h,T_(max)=(6.99±3.03)h,C_(max)=(0.6±0.41)μg/ml,AUC=(9.99±5.96)μg/(h·ml).结论:长效二氢奎尼丁治疗房颤时有效血药浓度为0.82～1.20μg/ml.AIM:To study the relationship between dihydroquinidine serum concentration and effect of treatment for artial fibrillation. METHODS:The serum concentrations of 10 patients with atrial fibrillation were measured with TDx after taking tablet of dihydroquinidine. RESULTS: T1/2(ka) was (2. 22 ± 1. 25) h, T1/2was was (8. 22 ± 4. 25) h, Tmax was (6. 99 ± 3.03)h,Cmax was (0. 6±0. 41) μg/ml ,AUC was (9. 99±5. 96)μg/(h · ml) and the serum concentration at steady state peak and bottom in 40 patients with atrial fibrillation were measured. CONCLUSION: The effective serum concentration for dihydroquinidine was 0. 82 ~ 1. 20μg/ml.

关 键 词：长效 二氢奎尼丁 血药浓度 心房纤颤 

分 类 号：R541.750.5[医药卫生—心血管疾病] R972.2[医药卫生—内科学]