纳洛酮对清醒家兔失血性休克的治疗作用  

THERAPEUTIC EFFECT OF NALOXONE HYDROCHLORIDE ON EXPERIMENTAL HEMORRHAGIC SHOCK IN RABBIT

作　　者：孟庆林[1] 龚正华[1] 贾永和 

机构地区：[1]军事医学科学院毒物药物研究所,北京100850

出　　处：《急诊医学》1998年第1期30-31,共2页

摘　　要：本文观察了纳洛酮对清醒家兔失血性休克的治疗作用。实验显示，纳洛酮0．1mg/kg与氢化可的松10mg／kg对血压及存活率无明显影响，去甲肾上腺素0．025mg／kg仅对血压有一过性升高。纳洛酮1．0及2．0mg／kg可使血压升高3．5－3．7kPa，持续30－60分钟，动物存活率平均提高75％，与对照组比较差别显著（P＜0．05），结果表明，纳洛酮对失血性休克低血压治疗有效，为临床应用提供了依据。By using experimental hemorrhagic shock model in albino rabbit, it was found that i. v. injection of both naloxone hydroch1oride (0.1mg/kg) and hydrocortisone (10mg/kg) was without any difference on blood pressure and the survival rate when compared with saline-treated control group. While noradrena1ine (0.025mg/kg, i. v. )only increased the blood pressure temporarily, naloxone hydrochloride (1. 0 and 2. 0mg/kg, i. v. ) increased it by 3. 5~3. 7 kPa, which usually lasted 30~60min, and made 75% of the experimented animals survived the shock.These results suggested that naloxone hydrochloride could be of some clinical use in the treatment of hemorrhagic shock.

关 键 词：纳洛酮 失血性休克 药物疗法 

分 类 号：R605.971[医药卫生—急诊医学]