婴幼儿喘息性疾病血白三烯B4浓度研究  

作　　者：刘焕 谢玉 

机构地区：[1]湖南省湘潭市妇幼保健院儿科,411104

出　　处：《当代医学》2009年第12期4-6,共3页Contemporary Medicine

摘　　要：目的检测喘息患儿血LTB4浓度,探讨血清LTB4与喘息、MP、RSV感染的关系。方法用ELISA法测定30例喘息及20例非喘息呼吸道感染患儿血清LTB4浓度,同时喘息组测MP-IgM、RSV-IgM,并进行分组对照。结果MP-IgM阳性4例(13.3%);RSV-IgM阳性12例(40%);喘息组LTB4水平高于非喘息组(t=3.639,P<0.05);MP-IgM阳性病例高于MP-IgM阴性病例(t=2.964,P<0.05);RSV-IgM阳性与RSV-IgM阴性病例LTB4水平没有统计学差异(t=0.301,P>0.05)。结论LTB4是引起婴幼儿喘息的重要炎症介质;MP感染可以增加体内LTB4水平。Objective To detect serum LTB4 concentration in infants with asthmatic diseases, and to explore the relationship with asthmatic diseases,Mp,RSV and atopic status. Methods Concentration of Serum LTB4 were measured by ELISA about asthmatic and non-asthmatic diseases but with respiratory tract infection infants. Serum Mp-IgM and RSV-IgM were also measured. Results The concentration of Serum LTB4 of asthmatic diseases group was higher than that of non-asthmatic group（P〈0.05）. In asthmatic diseases group,the concentration of Serum LTB4 of MP-IgM positive was higher than that of MP-IgM negative （P〈0.05）,but RSV-IgM positive group and RSV-IgM negative group had no sih, nifleant difference（P〉0.05）.Conclusion Concentration of LTB4 in infants with asthmatic diseases maintained a high level. LTB4 is one of the major factors that led to the infants asthma episode.

关 键 词：喘息 白三烯B4 支原体 呼吸道合胞病毒 婴幼儿 

分 类 号：R725.6[医药卫生—儿科]