联合免疫抑制剂对儿童难治性肾病综合征的临床疗效及血清细胞因子的影响  被引量:10

联合免疫抑制剂对儿童难治性肾病综合征的临床疗效及血清细胞因子的影响

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作  者:曾伟斌[1] 邓皓辉[1] 邝玉子[1] 

机构地区:[1]东莞市人民医院儿科,523018

出  处:《当代医学》2009年第13期3-4,共2页Contemporary Medicine

摘  要:目的探讨联合免疫抑制剂对儿童难治性肾病综合征(NS)的临床疗效及血清白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)的影响。方法将患者分为治疗组、对照组以及健康组,各32例。治疗组采用联合免疫抑制剂治疗,对照组单纯用激素治疗;观察治疗前及治疗后4、8、12周血中的IL-6和TNE-α浓度以及临床疗效和复发情况。结果血IL-6和TNE-α含量治疗前后自身对照及两组间比较,差异均有统计学意义("P<0.01")。随访20个月,治疗组复发率明显低于对照组("P<0.01")。结论联合免疫抑制剂能够减少小儿肾病复发,提高临床疗效,并且降低血IL-6和TNE-α的水平。Objective To study the effect of FK506 combined with glucocorticoidon nephritic syndrome (NS) in children and levels of IL-6 and TNF-α in blood .Methods The treatment grorp was treated with FK506 plus glucocorticoid, the control group with glucocorticoida lone, and a healthy control group was adopted, 32 cases in each group, the clinical effect and recurrence rate were observed, and levels of IL-6 and TNE- α in blood were determined before treatment and at the 4th, 8th, 12th weed after treatment.Results Significant difference of IL-6 and TNF- α levels in blood was found in either the pre- and post- treatment auto-control of both the treatment group and control group, or in the inter-group comparison of them (P〈0.01); clinical effectual so showed remarkable difference between the two groups (P〈0.01). Furthermore, there currence rate of the treatment group was lower than that of the control group showed by a 20-month follow-up (P〈0.01). Conclusion FK506 combined with glucocorticoid corld significantly reduce the recurrence rate and elevate the clinical effect in children with NS, it corld also lower the serum levels of IL-6 and TNF- α in patients.

关 键 词:肾病综合征(NS) FK506(普乐可复) 细胞因子 糖皮质激素 

分 类 号:R726.9[医药卫生—儿科]

 

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