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机构地区:[1]东莞市人民医院儿科,523018
出 处:《当代医学》2009年第13期3-4,共2页Contemporary Medicine
摘 要:目的探讨联合免疫抑制剂对儿童难治性肾病综合征(NS)的临床疗效及血清白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)的影响。方法将患者分为治疗组、对照组以及健康组,各32例。治疗组采用联合免疫抑制剂治疗,对照组单纯用激素治疗;观察治疗前及治疗后4、8、12周血中的IL-6和TNE-α浓度以及临床疗效和复发情况。结果血IL-6和TNE-α含量治疗前后自身对照及两组间比较,差异均有统计学意义("P<0.01")。随访20个月,治疗组复发率明显低于对照组("P<0.01")。结论联合免疫抑制剂能够减少小儿肾病复发,提高临床疗效,并且降低血IL-6和TNE-α的水平。Objective To study the effect of FK506 combined with glucocorticoidon nephritic syndrome (NS) in children and levels of IL-6 and TNF-α in blood .Methods The treatment grorp was treated with FK506 plus glucocorticoid, the control group with glucocorticoida lone, and a healthy control group was adopted, 32 cases in each group, the clinical effect and recurrence rate were observed, and levels of IL-6 and TNE- α in blood were determined before treatment and at the 4th, 8th, 12th weed after treatment.Results Significant difference of IL-6 and TNF- α levels in blood was found in either the pre- and post- treatment auto-control of both the treatment group and control group, or in the inter-group comparison of them (P〈0.01); clinical effectual so showed remarkable difference between the two groups (P〈0.01). Furthermore, there currence rate of the treatment group was lower than that of the control group showed by a 20-month follow-up (P〈0.01). Conclusion FK506 combined with glucocorticoid corld significantly reduce the recurrence rate and elevate the clinical effect in children with NS, it corld also lower the serum levels of IL-6 and TNF- α in patients.
关 键 词:肾病综合征(NS) FK506(普乐可复) 细胞因子 糖皮质激素
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