马钱子粉和马钱子微粉的治疗指数比较  

作　　者：朱建伟[1] 曹春玲[2] 刘瑾[1] 李克明[1] 闫雪生[1] 

机构地区：[1]山东省中医药研究院,250014 [2]济南市第一人民医院,250011

出　　处：《当代医学》2009年第13期144-145,共2页Contemporary Medicine

摘　　要：目的探讨马钱子超微粉碎的临床意义。方法急性毒性试验分别测定马钱子普通粉和超微粉的LD50;热板法和扭体法镇痛实验测定两种粉体的镇痛ED50。分别计算治疗指数(TI)。结果热板法测得TI分别为:普通粉:4.471、超微粉:4.280,TI2/TI1=0.9573;扭体法测得TI分别为:普通粉:4.637、超微粉:4.207,TI2/TI1=0.90733。结论马钱子经超微粉碎后,治疗指数降低。Objective To explore the clinical meaning of ultra micro powder of semen strychni .Methods The 50% lethal doses（LD50） of two kinds of powder of semen strychni were calculated and the 50% effective doses（ED50） of analgesia tests in hot-plate method and acetic-acid-induce twisting method were calculated also both on mice. Then the therapeutic indexes（TI） were calculated separately. Results The TI measuring from hot-plate method was 4.471 in ordinary powder and 4.380 in ultra micro powder of semen strychni, TI2/TI1=0.9573. The TI from acetic-acid-induce twisting method was 4.637 in ordinary powder and 4.207 in ultra micro powder of semen strychni, TI2/TI1=0.90733. Conclusion The therapeutic indexes of ultra micro powder of semen strychni are lower than that of ordinary powder

关 键 词：马钱子 普通粉 超微粉 LD50 ED50 TI 

分 类 号：R283[医药卫生—中药学] R285[医药卫生—中医学]