Respiratory face mask:a novel and cost-effective device for use during the application of myocardial ischemia in rats  

作　　者：Yuan YUAN Fei LI Yue-min WANG Rong-qing ZHANG Li-ping WEI Hai-chang WANG 

机构地区：[1]Department of Cardiology, Xijing Hospital the Fourth Military Medical University, Xi 'an 710032, China [2]Department of Physiology, the Fourth Military Medical University, Xi 'an 710032, China

出　　处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2009年第5期391-394,共4页浙江大学学报（英文版）B辑（生物医学与生物技术）

基　　金：(No.30600580) supported by the National Natural Science Foundation of China

摘　　要：To shorten operation time and improve survival rate of rats with myocardial ischemia or myocardial infarction,we use a novel device comprised of a face mask and a head/neck retainer in this study.We report the basic design of the novel respiratory face mask(RFM) and evaluate its performance in a rat model of myocardial ischemia.The device is cost-effective and easier to handle than other devices,such as tracheal intubation.Compared with conventional tracheal intubation,we found that RFM shortens operation time significantly while keeping blood indices normal;the mean operation time for rats in the mask group was(32±3) min,and that for the intubation group was(45±7) min(P<0.05).Moreover,the size and shape of the RFM can be changed according to the body weight of rats.In conclusion,RFM is an appropriate device for the establishment of myocardial infarction or ischemia-reperfusion in rats.To shorten operation time and improve survival rate of rats with myocardial ischemia or myocardial infarction, we use a novel device comprised of a face mask and a head/neck retainer in this study. We report the basic design of the novel respiratory face mask （RFM） and evaluate its performance in a rat model of myocardial ischemia. The device is cost-effective and easier to handle than other devices, such as tracheal intubation. Compared with conventional tracheal intubation, we found that RFM shortens operation time significantly while keeping blood indices normal; the mean operation time for rats in the mask group was （32±3） min, and that for the intubation group was （45±7） min （P〈0.05）. Moreover, the size and shape of the RFM can be changed according to the body weight of rats. In conclusion, RFM is an appropriate device for the establishment of myocardial infarction or ischemia-reperfusion in rats.

关 键 词：RATS Respiratory face mask （RFM） Myocardial ischemia Myocardial infarction 

分 类 号：S858.966[农业科学—临床兽医学] Q463[农业科学—兽医学]