年龄对C57BL/6小鼠非空间性学习记忆能力的影响  

Effect of Aging on Nonspatial Learning and Memory Ability in C57BL/6 Mice

作　　者：熊向东[1] 陈贵海[2] 

机构地区：[1]安徽省六安市人民医院,237005 [2]安徽医科大学第一附属医院神经内科,合肥230022

出　　处：《医学研究杂志》2009年第5期47-49,共3页Journal of Medical Research

基　　金：安徽省自然科学基金(03043708)

摘　　要：目的探讨C57BL/6小鼠非空间性学习记忆能力即再认记忆能力的年龄效应。方法用新物体再认实验测再认记忆能力。结果新物体再认实验有近一半老年小鼠几乎不探索或探索很少。结论新物体再认实验不适用于测C57BL/6小鼠非空间性学习记忆能力的年龄效应且不能作为检测其年龄相关非空间性学习记忆能力减退的方法。Objective To explore the effect of aging on nonspatial learning and memory ability or recognitive memory ability in C57BL/6 mice. Method The C57BL / 6 mice were used and novel - object recognition task was used to test the recognition memory ability. Results There was hardly exploring behavior in half of mice in the novel - object recognition task. Conclusion The novel - object recognition task is valueless to evaluate the effect of age on the nonspatial learning and memory ability in the C57BL/6 mice.

关 键 词：行为 记忆 小鼠 衰老 

分 类 号：R378.2[医药卫生—病原生物学] R285.5[医药卫生—基础医学]