贲门癌组织中CD3^+T细胞的数量与临床病理指标间的关系  

The Relationship between the Amount of CD3^+ T Cells and the Clinical Pathological Index in Gastric Cardia Carcinoma

作　　者：王公平[1] 冯笑山[1] 周博[1] 

机构地区：[1]河南科技大学第一附属医院肿瘤研究所/河南科技大学第一附属医院肿瘤科,洛阳471003

出　　处：《医学研究杂志》2009年第5期66-68,F0003,共4页Journal of Medical Research

摘　　要：目的探讨贲门癌中CD3+T细胞数量与贲门癌临床病理指标间的关系。方法用免疫组化Elivision法对42例贲门癌、18例癌旁组织以及12例正常贲门黏膜组织中的CD3+T细胞进行染色,并分析其与临床病理指标间的关系。结果(1)标本中CD3+T细胞平均数量从高到低依次为癌旁组织,癌组织和正常黏膜(P<0.05)。(2)贲门癌中CD3+T细胞平均数量与患者的年龄、性别、肿瘤的组织类型及分化程度无相关性(P>0.05)。(3)贲门癌中CD3+T细胞平均数量与肿瘤浸润深度及淋巴结转移情况呈明显负相关(P<0.05)。结论CD3+T细胞的数量与肿瘤浸润深度和淋巴结转移情况呈负相关,CD3+T细胞可能在延缓贲门癌的病情进展方面起到一定作用。Objective To explore the relationship between the amount of CD3^＋ T cells in gastric eardia carcinoma （GCC） samples and the clinical pathological index of GCC. Methods Immunohistochemieal Elivision method was used to detect CD3^＋ T cells in 42 cases of GCC samples, 18 cases of parancoplastic tissue and 12 cases of normal cardiac mucosa tissue. The relationship between CD3^＋ T cell and the clinical pathological index was analysed. Results （ 1 ） The order of the mean number of CD3^＋ T cells from high to low was para- neoplastic tissue, GCC and normal mucosa （ P 〈 0.05）. （2） The mean number of CD3^＋ T cells had no relationship with the age, sex, the histological types and the grades of carcinoma differentiation in GCC（P 〉0.05）. （3） The mean number of CD3^＋ T cells was negatively correlated with the depth of carcinoma invasion and the lymphatic metastisis （ P 〈 0.05）. Conclusion The mean number of the CD3^＋ T cells was negatively correlated with the depth of carcinoma invasion and the lymphatic metastisis. The CD3^＋ T cells may play a certain role in preventing the progress of GCC.

关 键 词：CD3^+ T细胞 贲门癌 免疫组织化学 病理指标 

分 类 号：R392.12[医药卫生—免疫学] R735.2[医药卫生—基础医学]