CD22基因多态性与中国南方汉族人群系统性红斑狼疮相关性研究  

Association analysis of CD22 polymorphism with the development of systemic lupus erythematosus in Southern Chinese Han people

作　　者：齐媛媛[1] 彭晖[2] 杨晓惠[3] 孔令杰[1] 高淑娜[1] 江峰[1] 付朝伟[1] 虞秀珍[3] 王宝涛[3] 许爱娥[4] 孟炜[1] 

机构地区：[1]上海复旦大学公共卫生学院流行病学教研室,200032 [2]浙江工商大学卫生所 [3]苏州大学第一附属医院皮肤科 [4]杭州市第三人民医院皮肤科

出　　处：《中华风湿病学杂志》2009年第5期301-304,共4页Chinese Journal of Rheumatology

基　　金：国家自然科学基金（30471485）

摘　　要：目的探讨CD22基因T〉A位点（SNPrs2267574）与中国南方汉族人群系统性红斑狼疮（SEE）的遗传易感性及其表型间的相关性。方法采用病例对照研究，收集215例病例和216例对照，应用聚合酶链反应-限制性片段长度多态性分析（PCR—RFLP）技术进行基因分型，分析基因与疾病关联性以及表型相关性。结果SLE患者组AT基因型的频率高于对照组（OR=1．68，95％CI：1．08～2．60，P=0．021）；以T等位基因为参照，A等位基因的OR=1．58，95％CI：1．09～2．29，P=0．015；且A等位基因频率在抗SSA抗体阳性组高于抗SSA抗体阴性组（OR=3．69，95％CI：2．08～6．52，P〈0．01）。结论在中国南方汉族人群中，CD22基因T〉A位点与SLE具有相关性，抗SSA抗体的产生与A等位基因有关。Objective To explore the association of CD22 gene T〉A locus （SNPrs2267574） with the development of systemic lupus erythematosus （SLE） and SLE phenotypos in Southern Chinese Han people. Methods Two hundreds fifteen cases and 216 normal controls were enrolled with the aim of case-control design, and the genotype was determined by PCR-RFLP. We calculated X2 and ORs for association study. Results In CD22 gene T〉A locus, there was significant difference of genotypes distribution between ,cases and controls （χ^2=6.086, P〈0.05 ）. The frequency of AT genotype was higher in cases than in controls （OR= 1.68, 95%CI： 1.08-2.60, P=0.021 ）, and A allele had a higher proportion in cases （OR=1.58, 95%CI： 1.09- 2.29, P=0.015）. Meanwhile, the frequency of A allele in patients with positive anti-SSA was higher than in patients with negative anti-SSA （OR=3.69, 95%CI： 2.08-6.52, P〈0.01 ）. Conclusion In Southern Chinese Han population, CD22 gene T〉A locus is associated with the development of SLE and the A allele has positive association with anti-SSA.

关 键 词：红斑狼疮 系统性 受体 白细胞介素2 多态性 单核苷酸 

分 类 号：R686[医药卫生—骨科学]