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作 者:刘辉[1] 李德安[1] 邓睛[1] 高本[1] 刘宁[1]
机构地区:[1]哈尔滨医科大学中国疾病预防控制中心地方病控制中心大骨节病防治研究所,150081
出 处:《中国地方病学杂志》2009年第3期338-341,共4页Chinese Jouranl of Endemiology
基 金:基金项目:哈尔滨市科技创新人才研究专项基金(2006RFQXS076)
摘 要:目的观察成年大骨节病患者膝关节间隙改变情况,为进一步进行的干预试验做基础准备。方法2007年在黑龙江省尚志市光辉村对40岁以上的成人进行大骨节病临床检杏,典型病例拍摄双侧膝关节X线片,测量关节间隙。每个膝关节内、外上髁关节面各取外、中、内3个点,记录测量结果。结果病村40岁以上人口307人.本次检查282人,检查率为91.9%,检出Ⅰ度以上病例80人,占28.4%。外上髁外、中、内3个部位测量值随着病情的加重明显降低[Ⅰ度分别为(5.85±0.17)、(4.84±0.17)、(4.36±0.18)mm,Ⅱ度分别为(5.11±0.43)、(4.24±0.34)、(3.48±0.28)mm,Ⅲ度分别为(3.59±0.78)、(3.10±0.56)、(2.14±0.62)mm;F外=6.547,F中=5.372,F内=10.302,P均〈0.05];而内上髁内、中、外3个部位的测量值并没有出现相同的趋势[Ⅰ度分另1为(3.66±0.17)、(3.47±0.17)、(3.73±0.18)mm,Ⅱ度分别为(3.55±0.34)、(3.54±0.29)、(4.35±0.35)mm,Ⅲ度分别为(3.19±0.72)、(3.92±0.66)、(4.51±0.72)mm;F内=0.351,F中:0.356,F外=1.883,P均〉0.05]。关节间隙〈5.00mm的测量点共618个,内上髁关节面测量点(363个)明显多于外上髁关节面(255个),二者比较差异有统计学意义(X2=9.59,P〈0.05)。结论光辉村成年大骨节病病例较多;伴随病情加重患者膝关节间隙呈变窄趋势,尤以外上髁表现明显;但患者以内上髁狭窄病变为多见。Objective To observe and scale knee joint space of the patients who suffered adults' Kasehin- Beck disease (KBD) in Shangzhi City of Heilongjiang Province in order to acquire basic knowledge for upcoming intervention trial. Methods Clinical test was proceeded in adults aged above 40 in Guanghui Village of Shangzhi City in 2007. In typical patients, bilateral knee X-ray was taken and knee joint space was scaled. Three points were chosen on inner and outer epicondyle of each knee and results were recorded. Results There were 307 peoples over the age of 40 in the village. Two hundred eighty-two accepted clinical test, in a rate of 91.9%. Eighty out of 282 suffered KBD, accounting for 28.4%. When the patients' condition became more serious, measurements from flank, middle, inside points on outer epicondyle of joint space presented a narrowing trend [degree [ Ⅰ:(5.85 ± 0.17), (4.84 ± 0.17), (4.36 ±0.18)mm; degree Ⅱ : (5.11 ± 0.43), (4.24 ±0.34), (3.48±0.28)ram; degreeⅢ : (3.59 ± 0.78), (3.10 ± 0.56), (2.14 ± 0.62)mm; Fflank,fnicddle,inside= 6.547,5.372,10.302, all P 〈 0.05], but those on inner epicondyle of joint space did not[degree : (3.66 ,±0.17), (3.47± 0.17), (3.73 ± 0.18)mm; degree Ⅱ : (3.55 ± 0.34), (3.54 ± 0.29), (4.35± 0.35)mm; degree Ⅲ : (3.19 ± 0.72), (3.92 ± 0.66), (4.51 ±0.72)mm; Finside,middel,flank = 0.351,0.356,1.883, all P 〉 0.05]. Joint space 〈 5.00 mm were found in 618, among which 363 were measured on inner epicondyle, obviously greater than those measured on outer epicondyle of joint space(255), the difference being statistically significant(x2 = 9.59, P 〈 0,05). Conclusions Adult cases of KBD occur in Guanghui Village. Knee joint space of adult patients narrows obviously, the more serious, the narrower, especially occurring more obviously on outer epicondyle, but frequently on inner epicondyle.
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