运动训练对糖尿病大鼠尾神经传导速度的影响  

The effect of exercises training on caudal nerve conduction velocity in diabetic rats

作　　者：李红卫[1] 江钟立[1] 吴亚文[1] 陈玲[2] 

机构地区：[1]南京医科大学第一附属医院康复医学科,210029 [2]南京医科大学生理学系

出　　处：《中国康复医学杂志》2009年第5期412-415,共4页Chinese Journal of Rehabilitation Medicine

摘　　要：目的:探讨运动训练对糖尿病大鼠尾神经传导速度(CNCV)的影响。方法:链脲霉素(STZ,55mg/kg)诱导的21只糖尿病大鼠随机平均分配到糖尿病运动8周组(A)、糖尿病运动4周组(B)和糖尿病对照组(C),实验结束时17只糖尿病大鼠存活,其中A组6只、B组6只和C组5只;12只正常血糖大鼠随机分为正常运动8周组(D,n=6)和正常对照组(E,n=6)。运动组大鼠游泳60min/d,5d/周。实验过程中分别于基线、第4周、第8周时测定大鼠血糖、体重和CNCV。结果:糖尿病大鼠基线时血糖显著高于正常血糖大鼠,A组大鼠运动第8周时血糖较基线显著降低(P<0.05)。第4周时糖尿病大鼠CNCV均显著低于正常血糖大鼠,A组大鼠CNCV显著高于B、C组。第8周时A、B组大鼠CNCV显著高于C组和基线水平(P<0.05),与正常血糖大鼠无显著差异。第8周时C组大鼠CNCV较基线水平明显降低,而D、E组大鼠CNCV高于基线水平。结论:运动训练可以预防和治疗糖尿病周围神经病变。Objective： To explore the effect of exercises on caudal nerve conduction velocity （CNCV） in streptozotocin-induced diabetic rats. Method： Twenty-one diabetic rats induced by streptozotocin （STZ, 55mg/kg） were randomly divided into diabetic group A with exercises for 8 weeks, diabetic group B with exercises for 4 weeks and diabetic control group C without exercises. Seventeen diabetic rats survived at the end of experiment, which were distributed respectively in group A （n=6）, group B （n=6） and group C （n=5）. Twelve SD rats with euglycemia were randomly divided into normal exercises 8 weeks group D （n=6） and normal control group E （n=6）. The exercises rats were forced to swim 60min/d with 5d/week. Body weights, blood glucose and CNCV in all rats were evaluated at the points of baseline, the 4th week and 8th week. Result： Blood glucose in diabetic rats were higher than that in rats with euglycemia （P〈0.05）. Blood glucose in group A decreased significantly after 8 weeks exercises in comparison with baseline （P〈0.05）. The CNCV were significantly lower in all diabetic groups than that in groups with euglycemia and were significantly higher in group A than those in groups B and C at the 4th week. The CNCV in groups A and B increased significantly beyond baseline （P〈0.05） and to normal level as the groups with euglycemia at the 8th week. The CNCV in group C at the 8th week decreased significantly in comparison with baseline （P〈0.05）. The CNCV in groups D and E at the 8th week increased significantly in comparison with baseline. Conclusion： Exercises training may prevent and treat the diabetic neuropathy.

关 键 词：运动训练 糖尿病神经病变 尾神经传导速度 

分 类 号：R587.1[医药卫生—内分泌] R87[医药卫生—内科学]