不同代钙拮抗剂在稳定性心绞痛治疗的临床研究  

Clinical Study of the Different of CCB on the Stable Angina Pectoris

作　　者：王海霞[1] 王立志[2] 

机构地区：[1]大连大学附属中山医院循环内科,大连116001 [2]大连大学附属中山医院药剂科,大连116001

出　　处：《中国现代医生》2009年第13期9-10,共2页China Modern Doctor

摘　　要：目的比较不同钙离子拮抗剂对稳定性心绞痛的治疗效果。方法分别采用第三代、第一代钙拮抗剂中的两种药物司乐平和硝苯地平治疗稳定性心绞痛患者,观察心绞痛缓解情况、运动平板试验情况、心率、血压的变化情况及不良反应。结果司乐平与硝苯地平都能改善心肌缺血,使心绞痛发作次数减少,都能产生副作用,只是随着时间的推移,司乐平组的副作用可消失。结论司乐平作为第三代钙拮抗剂在稳定性心绞痛的治疗上明显由于第一代钙拮抗剂硝苯地平。Objective To study the effect of the different of CCB on stable angina pectoris. Methods Lacidipine and nefidipine were given to treat the patients with stable angina pectoris. The accident of angina pectoris, treadmill test, change of heart rate and blood pressure, etc. and other side-effects were observed. Results Laeidipine and nifedipine all decreased myocardial isehemia and changed the side-effects, lacidipine＇s side-effects could dispear with time passed. Conclusion Lacidipine as the third CCB is better than nefidipine on treating the stable angina pectoris.

关 键 词：钙拮抗剂 运动平板试验 稳定性心绞痛 

分 类 号：R541.4[医药卫生—心血管疾病]