^(131)Ⅰ和他巴唑治疗甲亢的临床对照研究  

Clinical Comparison Study of Iodine 131 and Methimazole in Treatment of Patients with Hyperthyroidism

作　　者：罗晓寒[1] 

机构地区：[1]四川省罗江县人民医院,四川罗江618500

出　　处：《中国现代医生》2009年第13期70-71,73,共3页China Modern Doctor

摘　　要：目的探讨甲亢有效的治疗方法,提高患者的生活质量。方法100例符合条件的患者随机分为观察组和对照组各50例,观察组采用131Ⅰ治疗,对照组采用他巴唑治疗,比较两组患者的临床疗效、甲状腺功能低下(甲低)发生率及复发率和突眼发生率。结果观察组治愈36例(72.00%),好转11例(22.00%),无效3例(6.00%);对照组治愈15例(30.00%),好转26例(52.00%),无效9例(18.00%),两组疗效比较,观察组明显高于对照组(P<0.01)。甲低发生率和治愈后甲亢复发率存在差异(P<0.01)。结论131Ⅰ治疗甲亢效果优于他巴唑,疗效肯定、安全,具有一定的临床价值,值得临床应用推广。Objective To explore the therapeutic method of hyperthyroidism and improve the quality of life of patients. Methods 100 cases of eligible patients were divided randomly into the intervention group（50 eases） and the control group（50 cases）. The intervention group were treated with iodine 131, the control group were treated with methimazole. The curative efficacy,incidence of hypothyroidism,relapse and exophthalmos between these two groups were compared. Results In the intervention group, 36 cases（72.00% ） were found with complete re- mission, 11 cases （22.00%） with improved remission, 3 cases（6.00%） with no response. In control group, 15 cases （30.00%） were found with complete remission, 26 cases（52.00%） with improved remission, 9 cases （ 18.00% ） with no response. Compared two groups,the curative ef- ficacy of intervention group was higher（P 〈 0.01 ）. The incidence of hypothyroidism and relapse of hyperthyroidism had statistically significant difference（P〈0.01）. Conclusion Iodine 131 is effective and safe in treatment of hyperthyroidism, which is superior to methimazole,and hence is worthy of being recommended in clinical practice.

关 键 词：甲状腺功能亢进症 131I 他巴唑 

分 类 号：R581.1[医药卫生—内分泌]