早期通里攻下法对重症急性胰腺炎结局影响的系统评价  

Systematic evaluation of the therapeutic efficacy of Tongli Gongxia herbs on severe acute pancreatitis

作　　者：苗彬[1] 崔乃强[1] 李忠廉[1] 马涛[1] 赵光[1] 王心[1] 

机构地区：[1]天津医科大学南开临床学院南开医院全国胆胰疾病诊疗中心,天津市300100

出　　处：《世界华人消化杂志》2009年第10期1042-1047,共6页World Chinese Journal of Digestology

基　　金：十一五国家科技支撑计划基金资助项目;No.2006BAI04A15~~

摘　　要：目的:评价通里攻下法治疗重症急性胰腺炎(severeacutepancreatitis,SAP)的疗效.方法:检索2004-01/2008-12国内生物医学期刊发表的有关中医通里攻下法治疗SAP的随机对照临床试验(RCT)文献.根据入选及排除标准,有8项临床试验,628例SAP患者(中药治疗组335例,对照组293例)纳入本研究.使用RevMan4.2软件合并分析纳入研究的SAP患者的首次排便时间、住院时间、并发症发生率、手术率及病死率等结局指标.结果:中药治疗组的首次排便时间,住院天数的标准化均数差均明显低于对照组,且差异有显著性(SMD=-2.34,-1.91,均P<0.01).中药治疗组的并发症发生率、手术率、病死率的优势比均明显低于对照组,且差异有显著性(OR=0.36,0.41,0.31,均P<0.01).结论:应用通里攻下治疗能显著缩短重症急性胰腺炎患者的首次排便时间、住院时间,明显降低手术率、并发症发生率、病死率.AIM： To evaluate therapeutic efficiency of Tongli Gongxia treatments for severe acute pancreatitis. METHODS： Tongli Gongxia treatment for severe acute pancreatitis （SAP） of randomized clinical trial （RCT） literature was retrieved in domestic biological medicine journals during 2004-01 and 2008-12. According to selection and exclusion standard, eight clinical trials （a total 628 cases of SAP, 293 cases of Chinese medicine treatment group and 335 cases of the control group） were enrolled in the study. First defecation time, hospitalization, mortality, complication rate and operability were analyzed using Meta Analysis. Results analysis was performed using RevMan 4.2 software. RESULTS： First defecation time and days of hospitalization were significantly shorter in Chinese medicine treatment group than control group （SMD = -2.34, -1.91, both P 〈 0.01）. Operability, complication rate and mortality rate were significantly lower in Chinese medicine treatment group than the control group （OR = 0.36, 0.41, 0.31, all P 〈 0.01）. CONCLUSION： Tongli Gongxia treatment can shorten first defecation time, hospitalization and reduce the operability, complication rate, and mortality in the patients with severe acute pancreatitis.

关 键 词：重症急性胰腺炎 中药 疗效评价 病死率 系统评价 

分 类 号：R259[医药卫生—中西医结合]