抗核抗体与衰老的相关性  

The correlation study of autoimmunity antinuclear antibody and aging

作　　者：杨蓬勃[1] 谢志贤[1] 

机构地区：[1]卫生部北京医院检验科,100730

出　　处：《中华老年医学杂志》2009年第5期394-396,共3页Chinese Journal of Geriatrics

摘　　要：目的探讨年龄、性别对血清抗核抗体（ANA）表达的影响。方法对993例老年人进行血清ANA检测，并依年龄及性别不同分组，同时检测200例中青年健康体检者作对照分析。结果老年组ANA阳性率为29．1％，高于中青年组的14．0％（χ^2=5．047，P=0．025）。随年龄的增长，血清中ANA阳性率增高。60～岁组ANA阳性率为24．1％，70～岁组为30．5％，≥80岁组为33．6％。老年女性ANA阳性率为35．8％，高于男性的22．4％（χ^2=21．79，P〈0．05）。中青年组滴度为1：100的标本占阳性标本总数57．1％，滴度高于1：3200的标本为0，老年组滴度为1：100的标本占阳性标本总数36．3%，较中青年组有所下降，滴度高于1：3200的标本为7．6％，较中青年组有所升高。老年人进行ANA初筛，女性ANA滴度为小于1：320～1：1000，男性ANA滴度小于1：100-1：320，特异性可达90％左右。结论老年人ANA阳性率女性高于男性，并随年龄而逐渐升高。建议将该年龄段人群ANA初筛临界值定为女性1：320～1：1000，男性1：100-1：320。Objective To investigate the influences of age and sex on the expression of serum antinuclear antibody （ANA） and its titer level. Methods The serum ANA in 993 people aged 60 years and over were detected and titer of positive serum were analyzed. They were divided into different groups according to age and sex. Two hundred healthy cases aged less than 60 years were collected as control group. Results The serum ANA positive rate was increased with age and it was significantly higher in people aged 60 years and over than aged less than 60 years （29.1% vs. 14.0%, χ^2=5.024, P=0.025 ）. The serum ANA positive rates were 24. 1%, 30.5% and 33.6% in people aged 60-69 group, aged 70 -79 group and aged above 80 group. Among people aged 60 years and over, the positive rate was 35.8% in female group, which was higher than in male group （22.4%） （χ^2=21. 179, P= 0. 05 ）. The titre levels of the positive samples were increased with age. In control group, the samples with 1 ： 100 titre was 57.1% among the positive samples, which was higher than in the elderly group （36.3%）. And in control group, the samples with 1 ： 3200 titre was 0 among the positive samples, which was lower than in the elderly people group （7.6%）. The ANA preliminary screening in people aged 60 years and over showed that the titre level was less than 1 ： 320-1 ： 1000 in female and less than 1 ： 100-1 ： 320 in male. Its specificity could be up to about 90%. Conclusions The serum ANA positive rate in people aged 60 years and over is affected by age and sex. The positive rate is higher in female than in male and it is increased with age. It suggests that 1 ： 320 to 1 ： 1000 could be taken as ANA preliminary screening critical value in female and 1 ： 100 to 1 ： 320 in male.

关 键 词：抗体 抗核 自身免疫 衰老 

分 类 号：R686[医药卫生—骨科学]