老年突发性耳聋患者血浆同型半胱氨酸和肾上腺髓质素含量变化的意义  

Significance of changes of plasma levels of homocysteine and adrenomedullin in elderly patients with sudden sensorineural hearing loss

作　　者：陈松岳[1] 许敏达[1] 赵智翔[1] 

机构地区：[1]浙江医院耳鼻喉科,杭州310013

出　　处：《中华老年医学杂志》2009年第5期405-407,共3页Chinese Journal of Geriatrics

摘　　要：目的探讨同型半胱氨酸（Hcy）和肾上腺髓质素（ADM）血管活性物质与老年突发性耳聋（突聋）的关系。方法选取未经治疗的突聋患者80例作为研究组，选择性别、年龄相匹配的正常听力人群80例作为对照组，用荧光法定量检测Hcy浓度，用放射免疫法检测ADM浓度，对两组血浆Hcy、ADM浓度进行比较。结果老年突聋组血浆Hcy、ADM、TC、TG浓度分别为（13．81±2．88）μmol／L、（26．40±3．20）ng／L、（5．22±0．87）mmol／L、（1．80±0．12）mmol／L明显高于对照组[（11．56±2．80）μmol／L、（22．45±2．80）ng／L、（4．52±0．81）mmol／L、（1．52±0．13）mmol／L]，差异有统计学意义（t=5．03、8．22、7．48、3．85，P=0．000），比较两组中所有伴高血压者，突聋组中Hcy、ADM、TC、TG[（15．30±2．77）μmol／L、（29．40±2．80）ng／L、（5．48±0．98）mmol／L、（1．92±0．18）mmol／L]仍显著高于对照组[（12．80±2．62）μmol／L、（25．20±2．60）ng／L、（5．01±1．03）mmol／L、（1．62±0．15）mmol／L]，差异有统计学意义（t=4．03、7．01、3．25、7．80，P=0．000）；而两组的收缩压、舒张压水平差异无统计学意义（t=0．87、0．64，P=0．38、0．55）。结论Hcy、ADM浓度的变化提示其参与了老年突聋的发病过程，对了解病情、观察预后有一定的临床价值。Objective To explore the relationship between levels of plasma homocysteine （Hcy） and adrenomedullin （ADM） and sudden sensorineural hearing loss （SSHL） in elderly patients. Methods The 80 patients with SSHL but without any treatment were selecled as SSHL group, while 80 age- and sex-matehed subjects without SSHL were collected as the control group. The levels of plasma Hey and ADM were measured by fluorescence method and radioimmunoassay, respectively. And the levels of plasma Hcy, ADM, total cholesterol （TC） and triglyceride （TG） were compared between the two groups. Results The levels of plasma Hey, ADM, TC and TG were significantly higher in SSHI. group than in control group [（13.81 ±2.88）μmol/L vs. （ 11.56±2.80） μmol/L, （26.40±3.20）ng/L vs. （22.45±2.80）ng/L, （5.22±0.87）mmol/L vs. （4.52±0.81）mmol/L, （1.80 ±0.12）mmol/L vs.（1.52±0.13）mmol/L; t=5.03, 8.22, 7.48, 3.85, all P〈0.01）. When the two groups with hypertension were compared, the levels of plasma Hcy, ADM, TC and TG were （15.30±2.77）μmol/L, （29.40±2.80 ） ng/L, （5.48 ± 0.98 ） mmol/L and （1.92 ± 0.18 ） mmol/L in SSHL group, which were higher than those in control group [（12.80±2.62） μmol/L, （25.20 ± 2.60） ng/L,（5.01±1. 03）mmol/L,（1.62±0. 15）mmol/L] （t=4.03, 7.01, 3.25, 7.80,all P〈 0.01）. There were no differences in systolic and diastolic blood pressure between the two groups（t=0.87, 0.64; P=0. 38, 0. 55）. Conclusions The changes of plasma levels of Hey and ADM in the elderly suggest that they could involve in the pathogenic process of SSHL, which may provide referential value for understanding the state of the disease and judging the prognosis

关 键 词：听觉丧失 突发性 半胱氨酸 肾上腺髓质素 

分 类 号：R686[医药卫生—骨科学]